Relative risks of adverse events among older adults receiving opioids versus NSAIDs after hospital discharge: A nationwide cohort study

• Published in: PLoS medicine 2021-09, Vol.18 (9), p.e1003804-e1003804
• Main Authors: Herzig, Shoshana J, Anderson, Timothy S, Jung, Yoojin, Ngo, Long, Kim, Dae H, McCarthy, Ellen P
• Format: Article
• Language: English
• Subjects: Admission and discharge; Adverse and side effects; Aged; Aged patients; Aged, 80 and over; Analgesics; Analgesics, Opioid - adverse effects; Anti-Inflammatory Agents, Non-Steroidal - adverse effects; Beneficiaries; Cohort analysis; Complications and side effects; Delirium; Demography; Drug therapy; Drug-Related Side Effects and Adverse Reactions - diagnosis; Drug-Related Side Effects and Adverse Reactions - epidemiology; Drug-Related Side Effects and Adverse Reactions - mortality; Drugs; Duodenitis; Emergency medical care; Female; Gastritis; Generalized linear models; Health care; Hospital patients; Hospitalization; Hospitals; Humans; Incidence; Inflammation; Male; Medicaid; Medicare; Medicine and Health Sciences; Motility; Narcotics; Nausea; Nonsteroidal anti-inflammatory drugs; Older people; Opioids; Pain - diagnosis; Pain - drug therapy; Pain - epidemiology; Patient Discharge; Peer review; People and Places; Renal failure; Research and Analysis Methods; Retrospective Studies; Risk Assessment; Risk Factors; Side effects; Statistics; Time Factors; United States - epidemiology; Variables; Vomiting
• ISSN: 1549-1676; 1549-1277; 1549-1676
• DOI: 10.1371/journal.pmed.1003804

Although analgesics are initiated on hospital discharge in millions of adults each year, studies quantifying the risks of opioids and nonsteroidal anti-inflammatory drugs (NSAIDs) among older adults during this transition are limited. We sought to determine the incidence and risk of post-discharge adverse events among older adults with an opioid claim in the week after hospital discharge, compared to those with NSAID claims only. We performed a retrospective cohort study using a national sample of Medicare beneficiaries age 65 and older, hospitalized in United States hospitals in 2016. We excluded beneficiaries admitted from or discharged to a facility. We derived a propensity score that included over 100 factors potentially related to the choice of analgesic, including demographics, diagnoses, surgeries, and medication coadministrations. Using 3:1 propensity matching, beneficiaries with an opioid claim in the week after hospital discharge (with or without NSAID claims) were matched to beneficiaries with an NSAID claim only. Primary outcomes included death, healthcare utilization (emergency department [ED] visits and rehospitalization), and a composite of known adverse effects of opioids or NSAIDs (fall/fracture, delirium, nausea/vomiting, complications of slowed colonic motility, acute renal failure, and gastritis/duodenitis) within 30 days of discharge. After propensity matching, there were 13,385 beneficiaries in the opioid cohort and 4,677 in the NSAID cohort (mean age: 74 years, 57% female). Beneficiaries receiving opioids had a higher incidence of death (1.8% versus 1.1%; relative risk [RR] 1.7 [1.3 to 2.3], p < 0.001, number needed to harm [NNH] 125), healthcare utilization (19.0% versus 17.4%; RR 1.1 [1.02 to 1.2], p = 0.02, NNH 59), and any potential adverse effect (25.2% versus 21.3%; RR 1.2 [1.1 to 1.3], p < 0.001, NNH 26), compared to those with an NSAID claim only. Specifically, they had higher relative risk of fall/fracture (4.5% versus 3.4%; RR 1.3 [1.1 to 1.6], p = 0.002), nausea/vomiting (9.2% versus 7.3%; RR 1.3 [1.1 to 1.4], p < 0.001), and slowed colonic motility (8.0% versus 6.2%; RR 1.3 [1.1 to 1.4], p < 0.001). Risks of delirium, acute renal failure, and gastritis/duodenitis did not differ between groups. The main limitation of our study is the observational nature of the data and possibility of residual confounding. Older adults filling an opioid prescription in the week after hospital discharge were at higher risk for mortality and