Postprandial plasma glucose excursion is associated with an atherogenic lipid profile in individuals with type 2 diabetes mellitus: A cross-sectional study

Coronary heart disease (CHD) is a prevalent complication of type 2 diabetes mellitus (T2DM). The atherogenic low-density lipoprotein (LDL) cholesterol is an established risk factor of cardiovascular disease, and evidence also suggests that postprandial plasma glucose (PPG) levels closely delineate C...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2021-10, Vol.16 (10), p.e0258771-e0258771
Main Authors: Cheng, Po-Chung, Kao, Chia-Hung
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Blood pressure
Blood tests
Carbohydrates
Cardiovascular disease
Cardiovascular diseases
Cholesterol
Complications and side effects
Coronary artery disease
Coronary heart disease
Creatinine
Cross-sectional studies
Demographic aspects
Diabetes
Diabetes mellitus
Diabetes mellitus (non-insulin dependent)
Diagnosis
Endocrinology
Estrogens
Glucose
Health risks
Heart diseases
Hemoglobin
High density lipoprotein
Hyperglycemia
Hypothyroidism
Kidney diseases
Laboratories
Lipids
Low density lipoprotein
Medicine and Health Sciences
Metabolic syndrome
Physical Sciences
Plasma
Regression analysis
Risk analysis
Risk factors
Statins
Statistical analysis
Triglycerides
Type 2 diabetes
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Coronary heart disease (CHD) is a prevalent complication of type 2 diabetes mellitus (T2DM). The atherogenic low-density lipoprotein (LDL) cholesterol is an established risk factor of cardiovascular disease, and evidence also suggests that postprandial plasma glucose (PPG) levels closely delineate CHD mortality in diabetes. The investigators hypothesized that postprandial plasma glucose excursion (PPGE), defined as the difference between 2-hour PPG and fasting plasma glucose (FPG), may be associated with plasma LDL cholesterol levels in patients with T2DM. This study enrolled diabetic participants for whom FPG and lipid profile were sampled after a 12-hour fast, followed by PPG sampling two hours after consuming a standard meal with 75 grams of carbohydrates. The study enrolled 379 participants who were divided into PPGE tertiles according to the difference between their 2-hour PPG and FPG. Participants in the highest PPGE tertile had considerably greater plasma LDL cholesterol levels than patients in the lowest tertile (126.7 mg/dL vs. 99.5 mg/dL, P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0258771