The mobile emergency recovery intervention trial (MERIT): Protocol for a 3-year mixed methods observational study of mobile recovery outreach teams in Nevada’s emergency departments

• Published in: PloS one 2021-10, Vol.16 (10), p.e0258795-e0258795
• Main Authors: Smith, Krysti P, Oman, Roy F, Lu, Minggen, Dawkins, Ashley D, Harding, Robert W, Hepworth, Katherine, Wagner, Karla D
• Format: Article
• Language: English
• Subjects: Acceptability; Bayesian analysis; Care and treatment; CFR; Clinical trials; Drug abuse; Drug overdose; Drug use; Emergencies; Emergency management; Emergency medical care; Emergency medical services; Epidemics; Evaluation; Feasibility studies; Grants; Health sciences; Intervention; Interviews; Mathematical models; Medical care; Medicine and Health Sciences; Mental health; Mixed methods research; Mortality; Narcotics; Observational studies; Opioids; Overdose; Patient outcomes; Patient satisfaction; People and places; Prevention; Public health; Qualitative analysis; Quality management; Recovery (Medical); Rural areas; Social Sciences; Statistical inference; Statistical methods; Study Protocol; Substance abuse; Substance abuse treatment; Substance use; Teams
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0258795

Background The Substance Abuse and Mental Health Administration awarded State Targeted Response grants to support states' efforts to address the opioid epidemic. In Nevada, one component of this grant was mobile recovery outreach teams (MROTs) that utilized peer recovery support specialists to provide care for qualifying patients in emergency departments (EDs). The Mobile Emergency Recovery Intervention Trial (MERIT) is a mixed methods study to assess the feasibility/acceptability and effectiveness of the MROT intervention. This protocol mainly describes the R33 research activities and outcomes. The full protocol can be found protocols.io. Methods Data will be derived from state-level data sets containing de-identified emergency department visits, substance use disorder treatment records, and mortality files; in-person mixed methods interviews; participant observation; and self-report process evaluation forms. Primary outcomes include Medication Assisted Treatment (MAT) initiation and non-fatal overdose; secondary outcomes include MAT retention and fatal overdose. Quantitative hypotheses will be tested using generalized linear mixed effects models, Bayesian hierarchical models, and marginal Cox models. Qualitative interview data will be analyzed using an inductive thematic analysis procedure. Discussion It is impossible to conduct a randomized controlled trial of the effectiveness of the MROTs, given the ethical and logistical considerations of this intervention. This study's innovative design employs a mixed methods formative phase to examine feasibility and acceptability, and a quasi-experimental outcomes evaluation phase employing advanced statistical methods to mitigate bias and suggest causal inference regarding the effectiveness of the MROTs. Innovative interventions have been deployed in many states; evidence regarding their effectiveness is lacking, but critical to informing an effective public health response to the opioid epidemic.