Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study

• Published in: PloS one 2021-12, Vol.16 (12), p.e0260251-e0260251
• Main Authors: Virata, Michael D, Shenoi, Sheela V, Ladines-Lim, Joseph, Villanueva, Merceditas S, Barakat, Lydia A
• Format: Article
• Language: English
• Subjects: Acquired immune deficiency syndrome; AIDS; Biology and Life Sciences; Cardiovascular diseases; CD4 antigen; Chronic diseases; Cohort analysis; Complications and side effects; Coronaviruses; COVID-19; Demographic aspects; Diabetes; Disease control; Epidemics; Health risks; HIV; HIV patients; Hospital care; Human immunodeficiency virus; Infectious diseases; Lung diseases; Medicine and Health Sciences; Mortality; Prognosis; Public health; Urban areas
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0260251

There continue to be conflicting data regarding the outcomes of people with HIV (PWH) who have COVID-19 infection with most studies describing the early epidemic. We present a single site experience spanning a later timeframe from the first report on January 21, 2020 to January 20, 2021 and describe clinical outcomes and predictors of hospitalization among a cohort of PWH in an urban center in Connecticut, USA. Among 103 PWH with controlled HIV disease, hospitalization occurred in 33% and overall mortality was 1%. HIV associated factors (CD4 count, HIV viral suppression) were not associated with hospitalization. Chronic lung disease (OR: 3.35, 95% CI:1.28-8.72), and cardiovascular disease (OR: 3.4, 95% CI:1.27-9.12) were independently associated with hospitalization. An increasing number of non-communicable comorbidities increased the likelihood of hospitalization (OR: 1.61, 95% CI:1.22-2.13).