Effect of neonatal neuronal intensive care unit on neonatal encephalopathy

Prophylaxis of brain injury in newborns has been a main concern since the first neonatal neuronal intensive care unit (NNICU) was established in the world in 2008. The aim of this study was to outline and evaluate the unit's development by analyzing the demographics of the patients, the service...

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Published in:PloS one 2021-12, Vol.16 (12), p.e0261837
Main Authors: Lin, Lu, Liu, Weiqin, Mu, Jing, Zhan, Enmei, Wei, Hong, Hong, Siqi, Hua, Ziyu
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Birth weight
Brain
Brain - diagnostic imaging
Brain Diseases - diagnostic imaging
Brain injury
Brain research
Care and treatment
Child development
Children & youth
Childrens health
Cooperation
Demography
Education
Electroencephalography
Encephalopathy
Ethics
Female
Gestational age
Head injuries
Health aspects
Hospitals
Humans
Hypoglycemia
Hypothermia
Hypothermia, Induced
Infant, Newborn
Infants (Newborn)
Intensive care
Intensive Care Units, Neonatal
Laboratories
Magnetic Resonance Imaging
Male
Medical prognosis
Medicine and Health Sciences
Neonates
Neurodevelopment
Neurology
Neuroprotection
Newborn babies
Nutrition
Patients
Prophylaxis
Reflexes
Research and Analysis Methods
Risk factors
Seizures
Sepsis
Traumatic brain injury
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Liu, Weiqin
Mu, Jing
Zhan, Enmei
Wei, Hong
Hong, Siqi
Hua, Ziyu
description Prophylaxis of brain injury in newborns has been a main concern since the first neonatal neuronal intensive care unit (NNICU) was established in the world in 2008. The aim of this study was to outline and evaluate the unit's development by analyzing the demographics of the patients, the services delivered, the short-term outcomes before and after the establishment of NNICU. During the two investigation periods, 384 newborns were diagnosed or suspected as "neonatal encephalopathy", among which 185 patients admitted to NNICU between 2011.03.01 and 2012.09.30 before the establishment of NNICU were enrolled in the pre-NNICU group, another 199 neonates hospitalized during 2018.03.01 to 2019.09.30 were included in the post-NNICU group. Patients in the post-NNICU group were more likely to have seizures (P = 0.001), incomplete or absent primitive reflexes (P = 0.002), therapeutic hypothermia (P
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The aim of this study was to outline and evaluate the unit's development by analyzing the demographics of the patients, the services delivered, the short-term outcomes before and after the establishment of NNICU. During the two investigation periods, 384 newborns were diagnosed or suspected as "neonatal encephalopathy", among which 185 patients admitted to NNICU between 2011.03.01 and 2012.09.30 before the establishment of NNICU were enrolled in the pre-NNICU group, another 199 neonates hospitalized during 2018.03.01 to 2019.09.30 were included in the post-NNICU group. Patients in the post-NNICU group were more likely to have seizures (P = 0.001), incomplete or absent primitive reflexes (P = 0.002), therapeutic hypothermia (P&lt;0.001) and liquid control (P&lt;0.001) in acute phase. Meanwhile, amplitude-integrated electro encephalogram (aEEG) monitoring (P&lt;0.001) and cranial ultrasound (P&lt;0.001) were more often used in NNICU. Both of the follow-up rate in brain MRI and the assessment of neurodevelopment at 3 months were higher in the post-NNICU group (P&lt;0.001). In conclusion, the NNICU focused on the neonatal neurocritical care for the babies susceptible to NE with the guidance of evidence-based medicine, the establishment of NNICU is gradually improving and standardizing the neuroprotective therapy and clinical follow-up to improve neurodevelopmental prognosis of the NE patients in CHCMU.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0261837</identifier><identifier>PMID: 34972144</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Biology and Life Sciences ; Birth weight ; Brain ; Brain - diagnostic imaging ; Brain Diseases - diagnostic imaging ; Brain injury ; Brain research ; Care and treatment ; Child development ; Children &amp; youth ; Childrens health ; Cooperation ; Demography ; Education ; Electroencephalography ; Encephalopathy ; Ethics ; Female ; Gestational age ; Head injuries ; Health aspects ; Hospitals ; Humans ; Hypoglycemia ; Hypothermia ; Hypothermia, Induced ; Infant, Newborn ; Infants (Newborn) ; Intensive care ; Intensive Care Units, Neonatal ; Laboratories ; Magnetic Resonance Imaging ; Male ; Medical prognosis ; Medicine and Health Sciences ; Neonates ; Neurodevelopment ; Neurology ; Neuroprotection ; Newborn babies ; Nutrition ; Patients ; Prophylaxis ; Reflexes ; Research and Analysis Methods ; Risk factors ; Seizures ; Sepsis ; Traumatic brain injury</subject><ispartof>PloS one, 2021-12, Vol.16 (12), p.e0261837</ispartof><rights>COPYRIGHT 2021 Public Library of Science</rights><rights>2021 Lin et al. 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Both of the follow-up rate in brain MRI and the assessment of neurodevelopment at 3 months were higher in the post-NNICU group (P&lt;0.001). In conclusion, the NNICU focused on the neonatal neurocritical care for the babies susceptible to NE with the guidance of evidence-based medicine, the establishment of NNICU is gradually improving and standardizing the neuroprotective therapy and clinical follow-up to improve neurodevelopmental prognosis of the NE patients in CHCMU.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>34972144</pmid><doi>10.1371/journal.pone.0261837</doi><tpages>e0261837</tpages><orcidid>https://orcid.org/0000-0002-2108-7980</orcidid><oa>free_for_read</oa></addata></record>
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source PubMed Central (Open Access); Publicly Available Content Database
subjects Biology and Life Sciences
Birth weight
Brain
Brain - diagnostic imaging
Brain Diseases - diagnostic imaging
Brain injury
Brain research
Care and treatment
Child development
Children & youth
Childrens health
Cooperation
Demography
Education
Electroencephalography
Encephalopathy
Ethics
Female
Gestational age
Head injuries
Health aspects
Hospitals
Humans
Hypoglycemia
Hypothermia
Hypothermia, Induced
Infant, Newborn
Infants (Newborn)
Intensive care
Intensive Care Units, Neonatal
Laboratories
Magnetic Resonance Imaging
Male
Medical prognosis
Medicine and Health Sciences
Neonates
Neurodevelopment
Neurology
Neuroprotection
Newborn babies
Nutrition
Patients
Prophylaxis
Reflexes
Research and Analysis Methods
Risk factors
Seizures
Sepsis
Traumatic brain injury
title Effect of neonatal neuronal intensive care unit on neonatal encephalopathy
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