The impact of invisible-spreaders on COVID-19 transmission and work resumption

The global impact of coronavirus disease 2019 (COVID-19) is unprecedented, and many control and prevention measures have been implemented to test for and trace COVID-19. However, invisible-spreaders, who are associated with nucleic acid detection and asymptomatic infections, have received insufficie...

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Bibliographic Details
Published in:PloS one 2022-01, Vol.17 (1), p.e0252994-e0252994
Main Authors: Wu, Chao, Xu, Cong, Mao, Feng, Xu, Xiaolin, Zhang, Chan
Format: Article
Language:English
Subjects:
Acids
Analysis
Asymptomatic
Asymptomatic Infections - epidemiology
Big Data
Biology and Life Sciences
Brazil - epidemiology
Coronaviruses
COVID-19
COVID-19 - diagnosis
COVID-19 - epidemiology
COVID-19 - transmission
COVID-19 - virology
Data science
Disease transmission
Epidemics
Experiments
Germany - epidemiology
Humans
India - epidemiology
Infections
Italy - epidemiology
Medical research
Medicine and Health Sciences
Models, Theoretical
Nucleic acids
Outbreaks
Pandemics
People and places
Quarantine
SARS-CoV-2 - isolation & purification
Spreaders
Sweden - epidemiology
Time series
Viral diseases
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Summary:The global impact of coronavirus disease 2019 (COVID-19) is unprecedented, and many control and prevention measures have been implemented to test for and trace COVID-19. However, invisible-spreaders, who are associated with nucleic acid detection and asymptomatic infections, have received insufficient attention in the current COVID-19 control efforts. In this paper, we analyze the time series infection data for Italy, Germany, Brazil, India and Sweden since the first wave outbreak to address the following issues through a series of experiments. We conclude that: 1) As of June 1, 2020, the proportion of invisible-spreaders is close to 0.4% in Sweden, 0.8% in early Italy and Germany, and 0.4% in the middle and late stages. However, in Brazil and India, the proportion still shows a gradual upward trend; 2) During the spread of this pandemic, even a slight increase in the proportion of invisible-spreaders could have large implications for the health of the community; and 3) On resuming work, the pandemic intervention measures will be relaxed, and invisible-spreaders will cause a new round of outbreaks.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0252994