Characteristics and outcome of children with renal tumors in the Netherlands: The first five-year's experience of national centralization

Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, since 2015, pediatric oncology care for renal tumor...

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Bibliographic Details
Published in:PloS one 2022-01, Vol.17 (1), p.e0261729-e0261729
Main Authors: Roy, Prakriti, van Peer, Sophie E, de Witte, Martin M, Tytgat, Godelieve A M, Karim-Kos, Henrike E, van Grotel, Martine, van de Ven, Cees P, Mavinkurve-Groothuis, Annelies M C, Merks, Johannes H M, Kuiper, Roland P, Hol, Janna A, Janssens, Geert O R, de Krijger, Ronald R, Jongmans, Marjolijn C J, Drost, Jarno, van der Steeg, Alida F W, Littooij, Annemieke S, Wijnen, Marc H W A, van Tinteren, Harm, van den Heuvel-Eibrink, Marry M
Format: Article
Language:English
Subjects:
Abdomen
Adolescent
Age
Antineoplastic Combined Chemotherapy Protocols
Biobanks
Biology and Life Sciences
Biomaterials
Biomedical materials
Cancer therapies
Care and treatment
Chemotherapy
Child
Child, Preschool
Children
Dactinomycin
Decision making
Disease-Free Survival
Diseases
Epidemiology
Histology
Humans
Infant
Kidney cancer
Kidney Neoplasms - diagnostic imaging
Kidney Neoplasms - drug therapy
Kidneys
Medicine and Health Sciences
Neoplasm Staging
Netherlands
Oncology
Pathology
Patient outcomes
Patients
Pediatrics
Prognosis
R&D
Radiology
Registration
Research & development
Surgery
Survival
Treatment Outcome
Tumors
Ultrasonic imaging
Vincristine
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Description
Summary:Around 6% of all childhood malignancies represent renal tumors, of which a majority includes Wilms tumor (WT). Although survival rates have improved over the last decades, specific patients are still at risk for adverse outcome. In the Netherlands, since 2015, pediatric oncology care for renal tumors has been centralized in the Princess Máxima Center for Pediatric Oncology. Here, we describe experiences of the first 5 years of centralized care and explore whether this influences the epidemiological landscape by comparing data with the Netherlands Cancer Registry (NCR). We identified all patients
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0261729