Very high prevalence of infection with the human T cell leukaemia virus type 1c in remote Australian Aboriginal communities: Results of a large cross-sectional community survey

Infection with the human T cell leukaemia virus type 1 (HTLV-1) subtype C is endemic among Aboriginal people in central Australia. To provide insights into the risk factors for transmission, we conducted the first large-scale, community-based prevalence study in seven remote Aboriginal communities....

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2021-12, Vol.15 (12), p.e0009915
Main Authors: Einsiedel, Lloyd, Pham, Hai, Talukder, Mohammad Radwanur, Taylor, Kerry, Wilson, Kim, Kaldor, John, Gessain, Antoine, Woodman, Richard
Format: Article
Language:English
Subjects:
Adolescent
Adult
Adults
Aged
Australia
Australia - epidemiology
Australian aborigines
Biology and life sciences
Breastfeeding & lactation
Child
Child, Preschool
Children
Collaboration
Community
Community involvement
Community participation
Consent
Cross-Sectional Studies
Disease transmission
Ethics
Female
Gender
Guardians
Hematology
Hospitals
HTLV-I Infections
HTLV-I Infections - epidemiology
HTLV-I Infections - transmission
Human T-lymphotropic virus 1
Human T-lymphotropic virus 1 - classification
Human T-lymphotropic virus 1 - genetics
Human T-lymphotropic virus 1 - pathogenicity
Humans
Infections
Laboratories
Leukemia
Life Sciences
Lymphocytes
Lymphocytes T
Lymphoma, T-Cell
Lymphoma, T-Cell - epidemiology
Lymphoma, T-Cell - virology
Male
Medicine and Health Sciences
Middle Aged
Native Hawaiian or Other Pacific Islander
Native peoples
Nucleotide sequence
PCR
People and Places
Prevalence
Primary care
Proviruses
Proviruses - genetics
Proviruses - isolation & purification
Public health
Research methodology
Risk analysis
Risk Factors
Serology
Statistics
Surveying
Surveys and Questionnaires
Transmission
Tropical diseases
Viral Load
Viruses
Young Adult
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Description
Summary:Infection with the human T cell leukaemia virus type 1 (HTLV-1) subtype C is endemic among Aboriginal people in central Australia. To provide insights into the risk factors for transmission, we conducted the first large-scale, community-based prevalence study in seven remote Aboriginal communities. Residents >2 years old were invited to participate in the study between August 2014 and June 2018. HTLV-1 infection was defined as a positive western blot (WB) test or a positive HTLV-1 PCR. 720 community residents participated in the study (children
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0009915