Molecular mechanism of inhibitory effects of melatonin on prostate cancer cell proliferation, migration and invasion

The increasing incidence of prostate cancer (PCa) indicates an urgent need for the development of new effective drug therapy. There are limited options to treat the PCa, this study tried to determine a new therapy option for this acute cancer. Androgen-independent PCa cell lines PC3 and DU145 were t...

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Bibliographic Details
Published in:PloS one 2022-01, Vol.17 (1), p.e0261341
Main Authors: Nyamsambuu, Altannavch, Khan, Md Asaduzzaman, Zhou, Xi, Chen, Han-Chun
Format: Article
Language:English
Subjects:
Androgens
Apoptosis
Apoptosis - drug effects
Biochemistry
Biology and Life Sciences
Cell culture
Cell Line, Tumor
Cell migration
Cell Movement - drug effects
Cell proliferation
Cell Proliferation - drug effects
Chemotherapy
Circadian rhythm
Cluster analysis
Drug therapy
Endocrine system
G1 phase
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Genes
Genetic aspects
Health aspects
Humans
Insulin-like growth factor-binding protein 3
Interleukin 6
Life sciences
Male
Medicine and Health Sciences
Melatonin
Melatonin - pharmacology
Migration
Molecular biology
Mortality
Neoplasm Invasiveness
Nerve growth factor receptors
NF-κB protein
Patient outcomes
Physiology
Prostate cancer
Prostatic Neoplasms - drug therapy
Prostatic Neoplasms - genetics
Prostatic Neoplasms - metabolism
Prostatic Neoplasms - pathology
Research and analysis methods
Ribonucleic acid
RNA
RNA sequencing
Technology assessment
Transcription
Tumor cell lines
White people
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Summary:The increasing incidence of prostate cancer (PCa) indicates an urgent need for the development of new effective drug therapy. There are limited options to treat the PCa, this study tried to determine a new therapy option for this acute cancer. Androgen-independent PCa cell lines PC3 and DU145 were treated with different melatonin concentrations (0.1~3.5 mM) for 1~3 days and assessed cell migration, cell invasion, cycle arrest in G0/G1 phase as well as apoptosis. We utilized RNA-seq technology to analyze the transcriptional misregulation pathways in DU145 prostate cancer cell line with melatonin (0.5 mM) treatment. Data revealed 20031 genes were up and down-regulated, there were 271 genes that differentially expressed: 97 up-regulated (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0261341