Early discontinuation of adjuvant chemotherapy in patients with early-stage pancreatic cancer correlates with inferior survival: A multicenter population-based cohort study

The current study aimed to determine the association between timing and completion of adjuvant chemotherapy and outcomes in real-world patients with early-stage pancreatic cancer. In this multi-center cohort study patients with early-stage pancreatic cancer who were diagnosed from 2007-2017 and unde...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263250-e0263250
Main Authors: Muhammadzai, Javeria, Haider, Kamal, Moser, Michael, Chalchal, Haji, Shaw, John, Gardiner, Donald, Dueck, Dorie-Anna, Ahmed, Osama, Brunet, Bryan, Iqbal, Mussawar, Luo, Yigang, Beck, Gavin, Zaidi, Adnan, Ahmed, Shahid
Format: Article
Language:English
Subjects:
Adjuvant treatment
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Chemotherapy, Adjuvant - mortality
Cohort analysis
Correlation
Diagnosis
Event history analysis
Female
Follow-Up Studies
Humans
Male
Medical prognosis
Medical schools
Medicine
Medicine and Health Sciences
Metastasis
Methods
Middle Aged
Multivariate analysis
Neoplasm Recurrence, Local - drug therapy
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Oncology
Pancreatic cancer
Pancreatic Neoplasms - drug therapy
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Patients
Population studies
Population-based studies
Prognosis
Radiation
Radiation therapy
Relapse
Retrospective Studies
Risk factors
Surgery
Survival
Survival Rate
Variables
Withholding Treatment - statistics & numerical data
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Summary:The current study aimed to determine the association between timing and completion of adjuvant chemotherapy and outcomes in real-world patients with early-stage pancreatic cancer. In this multi-center cohort study patients with early-stage pancreatic cancer who were diagnosed from 2007-2017 and underwent complete resection in the province of Saskatchewan were examined. Cox proportional multivariate analyses were performed for correlation with recurrence and survival. Of 168 patients, 71 eligible patients with median age of 69 years and M:F of 37:34 were identified. Median time to the start of adjuvant therapy from surgery was 73 days. Of all patients, 49 (69%) patients completed adjuvant chemotherapy and 22 (31%) required early treatment discontinuation. Median recurrence-free survival of patients who completed treatment was 22 months (95%CI:15.8-28.2) vs. 9 months (3.3-14.7) if treatment was discontinued early (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263250