Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity

Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Multicentre retrospective cohort...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263739-e0263739
Main Authors: Luiken, Ina, Eisenmann, Stephan, Garbe, Jakob, Sternby, Hanna, Verdonk, Robert C, Dimova, Alexandra, Ignatavicius, Povilas, Ilzarbe, Lucas, Koiva, Peeter, Penttilä, Anne K, Regnér, Sara, Dober, Johannes, Wohlgemuth, Walter A, Brill, Richard, Michl, Patrick, Rosendahl, Jonas, Damm, Marko
Format: Article
Language:English
Subjects:
Abdomen
Adult
Aged
Authorship
Biology and Life Sciences
Care and treatment
Clinical Medicine
Cohort Studies
Comorbidity
Computed tomography
Diagnosis
Disease Progression
Emergency medical care
Ethics
Europe - epidemiology
Female
Gastroenterology
Health risks
Hospitals
Humans
Internal medicine
Kirurgi
Klinisk medicin
Lung diseases
Lung Diseases - epidemiology
Lung Diseases - etiology
Lung Diseases - pathology
Male
Medical and Health Sciences
Medicin och hälsovetenskap
Medicine
Medicine and Health Sciences
Middle Aged
Mortality
Pancreatitis
Pancreatitis - complications
Pancreatitis - diagnosis
Pancreatitis - epidemiology
Pancreatitis - pathology
Patient Acuity
Pleural Diseases - diagnosis
Pleural Diseases - epidemiology
Pleural Diseases - etiology
Pleural Diseases - pathology
Prevalence
Prognosis
Rank tests
Regression analysis
Research and Analysis Methods
Respiratory failure
Respiratory Insufficiency - diagnosis
Respiratory Insufficiency - epidemiology
Respiratory Insufficiency - etiology
Retrospective Studies
Subgroups
Surgery
Survival
Survival Analysis
Thorax
Tomography
Tomography, X-Ray Computed
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Summary:Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed. 358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263739