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Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity
Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable. To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients. Multicentre retrospective cohort...
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| Published in: | PloS one 2022-02, Vol.17 (2), p.e0263739-e0263739 |
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| container_end_page | e0263739 |
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| creator | Luiken, Ina Eisenmann, Stephan Garbe, Jakob Sternby, Hanna Verdonk, Robert C Dimova, Alexandra Ignatavicius, Povilas Ilzarbe, Lucas Koiva, Peeter Penttilä, Anne K Regnér, Sara Dober, Johannes Wohlgemuth, Walter A Brill, Richard Michl, Patrick Rosendahl, Jonas Damm, Marko |
| description | Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable.
To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients.
Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed.
358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p |
| doi_str_mv | 10.1371/journal.pone.0263739 |
| format | article |
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To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients.
Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed.
358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p<0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17-7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup.
Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0263739</identifier><identifier>PMID: 35130290</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Abdomen ; Adult ; Aged ; Authorship ; Biology and Life Sciences ; Care and treatment ; Clinical Medicine ; Cohort Studies ; Comorbidity ; Computed tomography ; Diagnosis ; Disease Progression ; Emergency medical care ; Ethics ; Europe - epidemiology ; Female ; Gastroenterology ; Health risks ; Hospitals ; Humans ; Internal medicine ; Kirurgi ; Klinisk medicin ; Lung diseases ; Lung Diseases - epidemiology ; Lung Diseases - etiology ; Lung Diseases - pathology ; Male ; Medical and Health Sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine and Health Sciences ; Middle Aged ; Mortality ; Pancreatitis ; Pancreatitis - complications ; Pancreatitis - diagnosis ; Pancreatitis - epidemiology ; Pancreatitis - pathology ; Patient Acuity ; Pleural Diseases - diagnosis ; Pleural Diseases - epidemiology ; Pleural Diseases - etiology ; Pleural Diseases - pathology ; Prevalence ; Prognosis ; Rank tests ; Regression analysis ; Research and Analysis Methods ; Respiratory failure ; Respiratory Insufficiency - diagnosis ; Respiratory Insufficiency - epidemiology ; Respiratory Insufficiency - etiology ; Retrospective Studies ; Subgroups ; Surgery ; Survival ; Survival Analysis ; Thorax ; Tomography ; Tomography, X-Ray Computed</subject><ispartof>PloS one, 2022-02, Vol.17 (2), p.e0263739-e0263739</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Luiken et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Luiken et al 2022 Luiken et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6769-e94d598587dbffcf34ac275cf4fa33739a7e29577c2b4e29a2d472183c84608a3</citedby><cites>FETCH-LOGICAL-c6769-e94d598587dbffcf34ac275cf4fa33739a7e29577c2b4e29a2d472183c84608a3</cites><orcidid>0000-0001-7838-5762 ; 0000-0001-8043-763X ; 0000-0001-7505-5880 ; 0000-0002-0387-0760 ; 0000-0003-4513-0506</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2626214453/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2626214453?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35130290$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://lup.lub.lu.se/record/e1886ba5-d035-45ed-a80a-3371cf237c11$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Wellner, Ulrich</contributor><creatorcontrib>Luiken, Ina</creatorcontrib><creatorcontrib>Eisenmann, Stephan</creatorcontrib><creatorcontrib>Garbe, Jakob</creatorcontrib><creatorcontrib>Sternby, Hanna</creatorcontrib><creatorcontrib>Verdonk, Robert C</creatorcontrib><creatorcontrib>Dimova, Alexandra</creatorcontrib><creatorcontrib>Ignatavicius, Povilas</creatorcontrib><creatorcontrib>Ilzarbe, Lucas</creatorcontrib><creatorcontrib>Koiva, Peeter</creatorcontrib><creatorcontrib>Penttilä, Anne K</creatorcontrib><creatorcontrib>Regnér, Sara</creatorcontrib><creatorcontrib>Dober, Johannes</creatorcontrib><creatorcontrib>Wohlgemuth, Walter A</creatorcontrib><creatorcontrib>Brill, Richard</creatorcontrib><creatorcontrib>Michl, Patrick</creatorcontrib><creatorcontrib>Rosendahl, Jonas</creatorcontrib><creatorcontrib>Damm, Marko</creatorcontrib><title>Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable.
To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients.
Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed.
358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p<0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17-7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup.
Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.</description><subject>Abdomen</subject><subject>Adult</subject><subject>Aged</subject><subject>Authorship</subject><subject>Biology and Life Sciences</subject><subject>Care and treatment</subject><subject>Clinical Medicine</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>Computed tomography</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Emergency medical care</subject><subject>Ethics</subject><subject>Europe - epidemiology</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>Health risks</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Internal medicine</subject><subject>Kirurgi</subject><subject>Klinisk medicin</subject><subject>Lung diseases</subject><subject>Lung Diseases - epidemiology</subject><subject>Lung Diseases - etiology</subject><subject>Lung Diseases - pathology</subject><subject>Male</subject><subject>Medical and Health Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Pancreatitis</subject><subject>Pancreatitis - complications</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - epidemiology</subject><subject>Pancreatitis - pathology</subject><subject>Patient Acuity</subject><subject>Pleural Diseases - diagnosis</subject><subject>Pleural Diseases - epidemiology</subject><subject>Pleural Diseases - etiology</subject><subject>Pleural Diseases - pathology</subject><subject>Prevalence</subject><subject>Prognosis</subject><subject>Rank tests</subject><subject>Regression analysis</subject><subject>Research and Analysis Methods</subject><subject>Respiratory failure</subject><subject>Respiratory Insufficiency - diagnosis</subject><subject>Respiratory Insufficiency - epidemiology</subject><subject>Respiratory Insufficiency - etiology</subject><subject>Retrospective Studies</subject><subject>Subgroups</subject><subject>Surgery</subject><subject>Survival</subject><subject>Survival Analysis</subject><subject>Thorax</subject><subject>Tomography</subject><subject>Tomography, X-Ray 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Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SWEPUB Lunds universitet full text</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Lunds universitet</collection><collection>SwePub Articles full text</collection><collection>Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luiken, Ina</au><au>Eisenmann, Stephan</au><au>Garbe, Jakob</au><au>Sternby, Hanna</au><au>Verdonk, Robert C</au><au>Dimova, Alexandra</au><au>Ignatavicius, Povilas</au><au>Ilzarbe, Lucas</au><au>Koiva, Peeter</au><au>Penttilä, Anne K</au><au>Regnér, Sara</au><au>Dober, Johannes</au><au>Wohlgemuth, Walter A</au><au>Brill, Richard</au><au>Michl, Patrick</au><au>Rosendahl, Jonas</au><au>Damm, Marko</au><au>Wellner, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-02-07</date><risdate>2022</risdate><volume>17</volume><issue>2</issue><spage>e0263739</spage><epage>e0263739</epage><pages>e0263739-e0263739</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Respiratory failure worsens the outcome of acute pancreatitis (AP) and underlying factors might be early detectable.
To evaluate the prevalence and prognostic relevance of early pleuropulmonary pathologies and pre-existing chronic lung diseases (CLD) in AP patients.
Multicentre retrospective cohort study. Caudal sections of the thorax derived from abdominal contrast enhanced computed tomography (CECT) performed in the early phase of AP were assessed. Independent predictors of severe AP were identified by binary logistic regression analysis. A one-year survival analysis using Kaplan-Meier curves and log rank test was performed.
358 patients were analysed, finding pleuropulmonary pathologies in 81%. CECTs were performed with a median of 2 days (IQR 1-3) after admission. Multivariable analysis identified moderate to severe or bilateral pleural effusions (PEs) (OR = 4.16, 95%CI 2.05-8.45, p<0.001) and pre-existing CLD (OR = 2.93, 95%CI 1.17-7.32, p = 0.022) as independent predictors of severe AP. Log rank test showed a significantly worse one-year survival in patients with bilateral compared to unilateral PEs in a subgroup.
Increasing awareness of the prognostic impact of large and bilateral PEs and pre-existing CLD could facilitate the identification of patients at high risk for severe AP in the early phase and thus improve their prognosis.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35130290</pmid><doi>10.1371/journal.pone.0263739</doi><tpages>e0263739</tpages><orcidid>https://orcid.org/0000-0001-7838-5762</orcidid><orcidid>https://orcid.org/0000-0001-8043-763X</orcidid><orcidid>https://orcid.org/0000-0001-7505-5880</orcidid><orcidid>https://orcid.org/0000-0002-0387-0760</orcidid><orcidid>https://orcid.org/0000-0003-4513-0506</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2022-02, Vol.17 (2), p.e0263739-e0263739 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_2626214453 |
| source | Publicly Available Content Database (Proquest) (PQ_SDU_P3); PubMed Central |
| subjects | Abdomen Adult Aged Authorship Biology and Life Sciences Care and treatment Clinical Medicine Cohort Studies Comorbidity Computed tomography Diagnosis Disease Progression Emergency medical care Ethics Europe - epidemiology Female Gastroenterology Health risks Hospitals Humans Internal medicine Kirurgi Klinisk medicin Lung diseases Lung Diseases - epidemiology Lung Diseases - etiology Lung Diseases - pathology Male Medical and Health Sciences Medicin och hälsovetenskap Medicine Medicine and Health Sciences Middle Aged Mortality Pancreatitis Pancreatitis - complications Pancreatitis - diagnosis Pancreatitis - epidemiology Pancreatitis - pathology Patient Acuity Pleural Diseases - diagnosis Pleural Diseases - epidemiology Pleural Diseases - etiology Pleural Diseases - pathology Prevalence Prognosis Rank tests Regression analysis Research and Analysis Methods Respiratory failure Respiratory Insufficiency - diagnosis Respiratory Insufficiency - epidemiology Respiratory Insufficiency - etiology Retrospective Studies Subgroups Surgery Survival Survival Analysis Thorax Tomography Tomography, X-Ray Computed |
| title | Pleuropulmonary pathologies in the early phase of acute pancreatitis correlate with disease severity |
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