Upregulated WTAP expression in colorectal cancer correlates with tumor site and differentiation

Few reports exist regarding the expression and function of Wilms' tumor 1-associated protein (WTAP) in colorectal cancer (CRC), and the evidence is controversial. Our analysis explored the expression of WTAP in CRC tissue, and analyzed its clinical and prognostic significance. WTAP expression w...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263749-e0263749
Main Authors: Dong, Xiao-Fang, Wang, Yan, Tang, Chih-Hsin, Huang, Bi-Fei, Du, Zhang, Wang, Qian, Shao, Jun-Kang, Lu, Hua-Jun, Wang, Chao-Qun
Format: Article
Language:English
Subjects:
Adenoma
Adult
Aged
Aged, 80 and over
Antibodies
Biology and Life Sciences
Case-Control Studies
Cell Cycle Proteins - metabolism
Cell Differentiation
Colon
Colon cancer
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - metabolism
Colorectal Neoplasms - pathology
Confidence intervals
Development and progression
Differentiation
Female
Gene expression
Gene Expression Regulation, Neoplastic
Genetic aspects
Health aspects
Hospitals
Humans
Male
Medical prognosis
Medicine and Health Sciences
Middle Aged
Neoplasm Invasiveness
Pathology
Physiological aspects
Prognosis
Regression analysis
RNA Splicing Factors - metabolism
Statistical analysis
Survival Analysis
Tissues
Tumor suppressor genes
Tumors
Up-Regulation
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Summary:Few reports exist regarding the expression and function of Wilms' tumor 1-associated protein (WTAP) in colorectal cancer (CRC), and the evidence is controversial. Our analysis explored the expression of WTAP in CRC tissue, and analyzed its clinical and prognostic significance. WTAP expression was significantly higher in CRC tissue than in colorectal adenoma and normal colorectal tissue. WTAP was highest in left colon tumor samples and negatively associated with tumor differentiation, as well as depth of tumor invasion. In multiple logistic regression analysis, independent predictors of WTAP expression in CRC included tumor in the left colon (odds ratio = 2.634; 95% confidence interval: 1.129-6.142; P = 0.025) and poorly differentiated tissue (0.072; 0.014-0.367; P = 0.002). No clear relationship was observed between CRC patient prognosis and WTAP expression. We suggest that WTAP expression is upregulated in CRC, highly expressed in left colon cancer and negatively correlated with tumor differentiation.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263749