The effect of transcutaneous auricular vagus nerve stimulation on HRV in healthy young people

Transcutaneous auricular vagus nerve stimulation (taVNS) has shown positive effects on a variety of diseases. Considering that decreased heart rate variability (HRV) is closely associated with morbidity and mortality for a variety of diseases, it is important to investigate the effect of taVNS on HR...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0263833-e0263833
Main Authors: Geng, Duyan, Liu, Xuanyu, Wang, Yan, Wang, Jiaxing
Format: Article
Language:English
Subjects:
Adult
Alzheimer's disease
Anxiety
Biology and Life Sciences
Brain research
Cross-Over Studies
Diseases
Electromagnetism
Engineering and Technology
Female
Health aspects
Healthy Volunteers
Heart - physiology
Heart beat
Heart failure
Heart Rate
Humans
Intervals
Laboratories
Male
Medicine and Health Sciences
Methods
Morbidity
Mortality
Nervous system
Oxidative stress
Pain
Parameters
Physiological aspects
Physiology
Power
Research and Analysis Methods
Social Sciences
Stimulation
Transcutaneous Electric Nerve Stimulation - methods
Vagus nerve
Vagus nerve stimulation
Vagus Nerve Stimulation - methods
Young Adult
Young adults
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Summary:Transcutaneous auricular vagus nerve stimulation (taVNS) has shown positive effects on a variety of diseases. Considering that decreased heart rate variability (HRV) is closely associated with morbidity and mortality for a variety of diseases, it is important to investigate the effect of taVNS on HRV. In Study 1, we conducted a two-stage cross-over trial to compare the effects of taVNS and sham taVNS (staVNS) on HRV. In Study 2, we systematically tested the effects of different taVNS parameters on high frequency (HF) component of HRV. The results showed that taVNS significantly increased measurements of root mean square of the difference between successive RR intervals (RMSSD), percentage of number of pairs of adjacent RR intervals differing greater than 50ms (pRR50), standard deviation of all RR intervals (SDRR), HF. Significantly, enhancement of HF and pRR50 persisted into recovery period. In addition, higher baseline LF/HF ratio was associated with greater LF/HF ratio decrease. Findings also showed that there was no significant difference in measurements of HF between different taVNS parameters. These studies suggest that taVNS could increase HRV, it may help taVNS in the treatment of low HRV related diseases. However, taVNS may not have parameter-specific effects on HRV.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263833