Preparation and evaluation of bilayer-core osmotic pump tablets contained topiramate

• Published in: PloS one 2022-02, Vol.17 (2), p.e0264457-e0264457
• Main Authors: Lin, Wen, Li, Yinke, Shi, Qiongzhi, Liao, Xiangru, Zeng, Yuan, Tian, Wei, Xie, Xiangyang, Liu, Hui
• Format: Article
• Language: English
• Subjects: Animals; Antiepileptic agents; Biological Availability; Biology and Life Sciences; Cellulose acetate; Chlorine compounds; Complications and side effects; Controlled release; Convulsions & seizures; Delayed-Action Preparations - pharmacokinetics; Delayed-Action Preparations - pharmacology; Dogs; Drug delivery systems; Drug dosages; Drug Evaluation, Preclinical; Drugs; Engineering and Technology; Evaluation; Experiments; Female; Male; Medicine and Health Sciences; Molecular weight; Optimization; Patient outcomes; Pharmaceuticals; Pharmacokinetics; Pharmacology; Pharmacy; Physical Sciences; Plasma levels; Polyethylene; Polyethylene glycol; Polyethylene oxide; Pushing; Sodium; Sodium chloride; Tablets; Theater; Topiramate; Topiramate - pharmacokinetics; Topiramate - pharmacology; Vehicles; Water chemistry
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0264457

Topiramate (TPM) was an antiepileptic agent commonly used in clinical. Studies showed that an oral preparation of TPM with extended-release manner could bring some benefits for epileptics. In this paper, controlled release push-pull osmotic pump (PPOP) tablets of sparingly water-soluble TPM were successfully prepared. This bi-layer tablet core mainly consisted of sodium chloride as osmotic promoting agent and polyethylene oxide as suspending and pushing agents. The influences of osmotic agents, pushing agents and the compositions of coating membrane on TPM release profiles were evaluated. An optimal formulation of TPM-PPOP was obtained through single-factor experiments. In vitro release tests showed that the optimum formulation could release TPM at an approximate zero-order rate up to 8 h. Pharmacokinetic behaviors of TPM-PPOP tablets were evaluated and compared with the immediate release capsules after an oral single dose in beagle dogs. Pharmacokinetics results demonstrated that the TPM-PPOP tablet was able to provide a prolonged release of TPM with longer tmax and mean residence time. Lower fluctuations of drug plasma levels could also be achieved with TPM-PPOP tablets. These results suggested that sparely water-soluble drugs as TPM can be designed to PPOP for efficacy and safety use.