The minipig intraoral dental implant model: A systematic review and meta-analysis

The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners...

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Bibliographic Details
Published in:PloS one 2022-02, Vol.17 (2), p.e0264475
Main Authors: Musskopf, Marta Liliana, Finger Stadler, Amanda, Wikesjö, Ulf Me, Susin, Cristiano
Format: Article
Language:English
Subjects:
Alveolar bone
Animal experimentation
Animals
Biology and Life Sciences
Bone Remodeling
Bone-implant interfaces
Calibration
Dental bonding
Dental Implantation, Endosseous - methods
Dental Implants
Dental prosthetics
Dentistry
Engineering and Technology
Healing
Health aspects
Heterogeneity
Histology
Hogs
Implant dentures
Jaw
Laboratories
Light microscopy
Mandible - surgery
Maximum likelihood method
Medicine and Health Sciences
Meta-analysis
Methods
Modelling
Models, Animal
Optical microscopy
Oral hygiene
Osseointegration
Periodontics
Physical Sciences
Premolars
Prostheses
Quality assessment
Quality control
Research and Analysis Methods
Reviews
Standard deviation
Statistical analysis
Swine
Swine, Miniature
Systematic review
Titanium
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Summary:The objective of this report was to provide a review of the minipig intraoral dental implant model including a meta-analysis to estimate osseointegration and crestal bone remodeling. A systematic review including PubMed and EMBASE databases through June 2021 was conducted. Two independent examiners screened titles/abstracts and selected full-text articles. Studies evaluating titanium dental implant osseointegration in native alveolar bone were included. A quality assessment of reporting was performed. Random-effects meta-analyses and meta-regressions were produced for bone-implant contact (BIC), first BIC, and crestal bone level. 125 out of 249 full-text articles were reviewed, 55 original studies were included. Quality of reporting was generally low, omissions included animal characteristics, examiner masking/calibration, and sample size calculation. The typical minipig model protocol included surgical extraction of the mandibular premolars and first molar, 12±4 wks post-extraction healing, placement of three narrow regular length dental implants per jaw quadrant, submerged implant healing and 8 wks of osseointegration. Approximately 90% of studies reported undecalcified incandescent light microscopy histometrics. Overall, mean BIC was 59.88% (95%CI: 57.43-62.33). BIC increased significantly over time (p 90%, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0264475