The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study

Birth defects have been consistently associated with elevated childhood cancer risks; however, the relationship between congenital heart disease (CHD) and childhood cancer remains conflicting. Considering the increasing patient population with CHD after improvements in their life expectancies, insig...

Full description

Saved in:
Bibliographic Details
Published in:PLoS medicine 2022-02, Vol.19 (2), p.e1003903-e1003903
Main Authors: Kampitsi, Christina-Evmorfia, Mogensen, Hanna, Feychting, Maria, Tettamanti, Giorgio
Format: Article
Language:English
Subjects:
Age
Biology and Life Sciences
Birth defects
Cancer
Cancer in children
Cardiovascular disease
Child
Children
Codes
Cohort analysis
Cohort Studies
Complications and side effects
Congenital defects
Congenital diseases
Congenital heart disease
Coronary artery disease
Diagnosis
Down syndrome
Down Syndrome - complications
Down Syndrome - epidemiology
Down's syndrome
Heart Defects, Congenital - diagnosis
Heart Defects, Congenital - epidemiology
Heart diseases
Hepatoblastoma
Humans
Leukemia
Liver Neoplasms
Lymphoma
Lymphomas
Medical diagnosis
Medicin och hälsovetenskap
Medicine and Health Sciences
Nervous system
Neuroblastoma
Patients
Pediatric research
Population
Population studies
Population-based studies
Regression analysis
Risk Factors
Sweden - epidemiology
Tumors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Birth defects have been consistently associated with elevated childhood cancer risks; however, the relationship between congenital heart disease (CHD) and childhood cancer remains conflicting. Considering the increasing patient population with CHD after improvements in their life expectancies, insights into this relationship are particularly compelling. Thus, we aimed to determine the relationship between CHD and cancer in Swedish children. All individuals registered in the Swedish Medical Birth Register (MBR) between 1973 and 2014 were included in this population-based cohort study (n = 4,178,722). Individuals with CHD (n = 66,892) were identified from the MBR and National Patient Register, whereas cancer diagnoses were retrieved from the Swedish Cancer Register. The relationship between CHD and childhood cancer (
ISSN:1549-1676
1549-1277
1549-1676
DOI:10.1371/journal.pmed.1003903