Dietary choline in gonadectomized kittens improved food intake and body composition but not satiety, serum lipids, or energy expenditure

Gonadectomy is a major risk factor for feline obesity. The lipotropic effects of choline have demonstrated benefits for growth and carcass composition in livestock. The consumption of supplemental choline on body weight (BW), body composition, lipid metabolism, energy expenditure (EE), and serum sat...

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Bibliographic Details
Published in:PloS one 2022-03, Vol.17 (3), p.e0264321-e0264321
Main Authors: Godfrey, Hannah, Rankovic, Alexandra, Grant, Caitlin E, Shoveller, Anna Kate, Bakovic, Marica, Abood, Sarah K, Verbrugghe, Adronie
Format: Article
Language:English
Subjects:
Acclimation
Acclimatization
Accretion
Analysis
Animals
Biology and Life Sciences
Body Composition
Body fat
Body mass index
Body Weight
Body weight gain
Calorimetry
Cats
Choline
Chromatography
Density
Deposition
Diet
Diet - veterinary
Disease prevention
Dry matter
Dual energy X-ray absorptiometry
Eating
Energy
Energy expenditure
Energy Intake
Energy Metabolism
Energy requirements
Female
Food
Food composition
Food intake
Gonadectomy
High density lipoprotein
Homocysteine
Hormones
Juveniles
Laboratory animals
Lipid metabolism
Lipids
Lipoproteins
Liver
Livestock
Male
Meals
Medicine and Health Sciences
Metabolism
Nutrition research
Obesity
Peptides
Physical Sciences
Physiological aspects
Proteins
Quotients
Risk analysis
Risk factors
Satiety
Serum lipids
Substrates
Triglycerides
Veterinary colleges
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Summary:Gonadectomy is a major risk factor for feline obesity. The lipotropic effects of choline have demonstrated benefits for growth and carcass composition in livestock. The consumption of supplemental choline on body weight (BW), body composition, lipid metabolism, energy expenditure (EE), and serum satiety hormones were evaluated in 15 gonadectomized male kittens. Kittens were offered a base diet formulated for growth (3310mg choline/kg dry matter [DM]) to daily energy requirements (DER) over an 11-week acclimation. Post-gonadectomy, kittens were assigned to a base diet (CONTROL, n = 7) or choline group (base diet with additional choline at 300mg/kg BW0.75 as a top dress) (CHOLINE, n = 8). For 12-weeks post-neuter, kittens were offered three times their DER over three meals to mimic ad libitum feeding. At week -1 and 12, body composition was assessed using dual energy x-ray absorptiometry (DXA), 24-hour indirect calorimetry was performed for EE and respiratory quotients (RQ), and fasted serum samples were analyzed for lipid compounds and satiety hormones. Daily food intake (FI) and weekly BW were measured. Data was analyzed as a repeated measures of variance (ANCOVA) using the GLIMMIX procedure with time and group as fixed effects. CHOLINE had lower mean daily FI and lower rates of BW accretion (P0.05) between groups, but both groups experienced a decrease in low-density lipoproteins and increase in high-density lipoproteins (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0264321