Prognostic impact of prognostic nutritional index on renal cell carcinoma: A meta-analysis of 7,629 patients

Prognostic nutritional index (PNI) is a parameter which reflects nutritional and inflammatory status. The prognostic value of PNI in renal cell carcinoma (RCC) remains in debate. The aim of this study is to evaluate the prognostic value and clinicopathological features of PNI in RCC. A literature se...

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Bibliographic Details
Published in:PloS one 2022-03, Vol.17 (3), p.e0265119-e0265119
Main Authors: Peng, Qingping, Liu, Ling, Li, Ting, Lei, Changjiang, Wan, Huan
Format: Article
Language:English
Subjects:
Cancer
Cancer therapies
Carcinoma, Renal cell
Carcinoma, Renal Cell - diagnosis
Community health care
Confidence intervals
Differentiation
Female
Health services
Hospitals
Humans
Inflammation
Kidney cancer
Kidney Neoplasms
Laboratories
Male
Medical prognosis
Medicine and Health Sciences
Meta-analysis
Metastasis
Necrosis
Nutrition Assessment
Physical Sciences
Prognosis
Renal cell carcinoma
Research and Analysis Methods
Surgery
Survival
Tumors
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Summary:Prognostic nutritional index (PNI) is a parameter which reflects nutritional and inflammatory status. The prognostic value of PNI in renal cell carcinoma (RCC) remains in debate. The aim of this study is to evaluate the prognostic value and clinicopathological features of PNI in RCC. A literature search was performed in the databases of PubMed, Embase, Web of Science, and Cochrane Library. Hazard ratios (HRs), odds ratios (ORs), and 95% confidence intervals (CIs) were extracted for meta-analysis. The association between PNI and overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), progression-free survival (PFS), recurrence-free survival (RFS), and clinicopathological factors were evaluated. Eleven studies involving 7,629 patients were included for meta-analysis. A decreased PNI was shown to be a significant predictor of worse OS (HR = 2.00, 95%CI = 1.64-2.42, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0265119