Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery

The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were fo...

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Bibliographic Details
Published in:PloS one 2022-03, Vol.17 (3), p.e0266296
Main Authors: Fida, Saima, Jalil, Aamir, Habib, Rukhshanda, Akhlaq, Muhammad, Mahmood, Arshad, Minhas, Muhammad Usman, Khan, Kifayat Ullah, Nawaz, Asif
Format: Article
Language:English
Subjects:
Adhesives
Administration, Oral
Antibiotics
Antiinfectives and antibacterials
Antimicrobial activity
Antimicrobial agents
Biological Availability
Biology and Life Sciences
Castor oil
Childbirth
Complications and side effects
Delivery, Obstetric
Dilution
Disinfection & disinfectants
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Drug dosages
E coli
Emulsification
Emulsions
Excipients
Female
Health aspects
Humans
Infections
Iodine
Iodine in the body
Mucosa
Mucus
Nanoparticles
Particle Size
Patient compliance
Patient outcomes
Pharmaceutical sciences
Pharmacy
Phase diagrams
Physical Sciences
Pregnancy
Solubility
Stability tests
Surface-Active Agents
Surfactants
Ternary systems
Vagina
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Description
Summary:The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were formulated using castor oil as the oil phase, cremophor ethoxylated (CrEL) as a surfactant and after screening a number of vehicles, PEG 400 was employed as co-surfactant. Self-emulsification time, thermodynamic stability tests, robustness to dilution, percent transmittance, droplet size, and drug release were measured. Ternary phase diagrams were plotted to determine the area of emulsification. When compared to the commercial formulation, dissolving experiments revealed that the iodine from the SNEDDS enhanced aqueous solubility. In-vitro iodine release was determined to be around 15% per hour, with muco-adhesive and, muco-penetrating characteristics showing a 38-fold improvement. Furthermore, SNEDDS demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Similarly, when compared to marketed drugs, in-vitro drug absorption profile from the manufactured SNEDDS shown to be much higher. According to these results iodine containing SNEDDS could be a useful new formulation for iodine mucosal usage.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0266296