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Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery
The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were fo...
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Published in: | PloS one 2022-03, Vol.17 (3), p.e0266296 |
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description | The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were formulated using castor oil as the oil phase, cremophor ethoxylated (CrEL) as a surfactant and after screening a number of vehicles, PEG 400 was employed as co-surfactant. Self-emulsification time, thermodynamic stability tests, robustness to dilution, percent transmittance, droplet size, and drug release were measured. Ternary phase diagrams were plotted to determine the area of emulsification. When compared to the commercial formulation, dissolving experiments revealed that the iodine from the SNEDDS enhanced aqueous solubility. In-vitro iodine release was determined to be around 15% per hour, with muco-adhesive and, muco-penetrating characteristics showing a 38-fold improvement. Furthermore, SNEDDS demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Similarly, when compared to marketed drugs, in-vitro drug absorption profile from the manufactured SNEDDS shown to be much higher. According to these results iodine containing SNEDDS could be a useful new formulation for iodine mucosal usage. |
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Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were formulated using castor oil as the oil phase, cremophor ethoxylated (CrEL) as a surfactant and after screening a number of vehicles, PEG 400 was employed as co-surfactant. Self-emulsification time, thermodynamic stability tests, robustness to dilution, percent transmittance, droplet size, and drug release were measured. Ternary phase diagrams were plotted to determine the area of emulsification. When compared to the commercial formulation, dissolving experiments revealed that the iodine from the SNEDDS enhanced aqueous solubility. In-vitro iodine release was determined to be around 15% per hour, with muco-adhesive and, muco-penetrating characteristics showing a 38-fold improvement. Furthermore, SNEDDS demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Similarly, when compared to marketed drugs, in-vitro drug absorption profile from the manufactured SNEDDS shown to be much higher. According to these results iodine containing SNEDDS could be a useful new formulation for iodine mucosal usage.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0266296</identifier><identifier>PMID: 35358270</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adhesives ; Administration, Oral ; Antibiotics ; Antiinfectives and antibacterials ; Antimicrobial activity ; Antimicrobial agents ; Biological Availability ; Biology and Life Sciences ; Castor oil ; Childbirth ; Complications and side effects ; Delivery, Obstetric ; Dilution ; Disinfection & disinfectants ; Drug delivery ; Drug delivery systems ; Drug Delivery Systems - methods ; Drug dosages ; E coli ; Emulsification ; Emulsions ; Excipients ; Female ; Health aspects ; Humans ; Infections ; Iodine ; Iodine in the body ; Mucosa ; Mucus ; Nanoparticles ; Particle Size ; Patient compliance ; Patient outcomes ; Pharmaceutical sciences ; Pharmacy ; Phase diagrams ; Physical Sciences ; Pregnancy ; Solubility ; Stability tests ; Surface-Active Agents ; Surfactants ; Ternary systems ; Vagina</subject><ispartof>PloS one, 2022-03, Vol.17 (3), p.e0266296</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Fida et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fida, Saima</au><au>Jalil, Aamir</au><au>Habib, Rukhshanda</au><au>Akhlaq, Muhammad</au><au>Mahmood, Arshad</au><au>Minhas, Muhammad Usman</au><au>Khan, Kifayat Ullah</au><au>Nawaz, Asif</au><au>Rai, Vineet Kumar</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-03-31</date><risdate>2022</risdate><volume>17</volume><issue>3</issue><spage>e0266296</spage><pages>e0266296-</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The major goal of this project was to formulate iodine-based self nano-emulsifying drug delivery system to provide improve antimicrobial activity and enhanced mucosal residence time via mucus penetration. Iodine SNEDDS (Self nano-emulsifying drug delivery system) with different concentration were formulated using castor oil as the oil phase, cremophor ethoxylated (CrEL) as a surfactant and after screening a number of vehicles, PEG 400 was employed as co-surfactant. Self-emulsification time, thermodynamic stability tests, robustness to dilution, percent transmittance, droplet size, and drug release were measured. Ternary phase diagrams were plotted to determine the area of emulsification. When compared to the commercial formulation, dissolving experiments revealed that the iodine from the SNEDDS enhanced aqueous solubility. In-vitro iodine release was determined to be around 15% per hour, with muco-adhesive and, muco-penetrating characteristics showing a 38-fold improvement. Furthermore, SNEDDS demonstrated significant antibacterial efficacy against Escherichia coli and Staphylococcus aureus. Similarly, when compared to marketed drugs, in-vitro drug absorption profile from the manufactured SNEDDS shown to be much higher. According to these results iodine containing SNEDDS could be a useful new formulation for iodine mucosal usage.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35358270</pmid><doi>10.1371/journal.pone.0266296</doi><tpages>e0266296</tpages><orcidid>https://orcid.org/0000-0002-1145-3414</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Adhesives Administration, Oral Antibiotics Antiinfectives and antibacterials Antimicrobial activity Antimicrobial agents Biological Availability Biology and Life Sciences Castor oil Childbirth Complications and side effects Delivery, Obstetric Dilution Disinfection & disinfectants Drug delivery Drug delivery systems Drug Delivery Systems - methods Drug dosages E coli Emulsification Emulsions Excipients Female Health aspects Humans Infections Iodine Iodine in the body Mucosa Mucus Nanoparticles Particle Size Patient compliance Patient outcomes Pharmaceutical sciences Pharmacy Phase diagrams Physical Sciences Pregnancy Solubility Stability tests Surface-Active Agents Surfactants Ternary systems Vagina |
title | Development of mucus-penetrating iodine loaded self-emulsifying system for local vaginal delivery |
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