To what extent do people living with HIV, people on pre-exposure prophylaxis, doctors and pharmacists endorse 90-day dispensing of antiretroviral therapy in France?

• Published in: PloS one 2022-04, Vol.17 (4), p.e0265166-e0265166
• Main Authors: Jacomet, Christine, Goncalves, Émilie, Lambert, Céline, Chedorge, Didier, Puglièse-Wehrlen, Sylvia, Billaud, Éric, Zucman, David, Simon, Anne, Arvieux, Cédric, Trout, Hervé, Laurandin, Bruno, Maarek, René, Raymond, Isabelle, Puglièse, Pascal, Langlois, Julie, Certain, Agnès
• Format: Article
• Language: English
• Subjects: Anti-HIV Agents - therapeutic use; Anti-Retroviral Agents - therapeutic use; Antiretroviral agents; Antiretroviral drugs; Antiretroviral therapy; Antiviral agents; Autonomy; Beliefs, opinions and attitudes; Biology and Life Sciences; Coronaviruses; Cost control; COVID-19; Disease prevention; Dispensing; Doctors; Drug interaction; Drug interactions; Drug stores; Drug therapy; Health care; Health insurance; HIV; HIV Infections - epidemiology; HIV patients; Hospitals; Housing; Human immunodeficiency virus; Humans; Infectious diseases; Insurance coverage; Internal medicine; Medicine and Health Sciences; Pandemics; Patients; People and Places; Pharmaceutical industry; Pharmacists; Physicians; Polls & surveys; Pre-Exposure Prophylaxis; Prophylaxis; Quality of Life; Severe acute respiratory syndrome coronavirus 2; Shortages; Social aspects; Social conditions; Surveys; Well being
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0265166

The WHO 95-95-95 targets for 2030 do not imply that people living with HIV (PLHIV) achieve a good quality of life. The current 30-day dispensing interval for antiretroviral (ART) burdens the healthcare system. Lengthening dispensing intervals could alleviate this burden as well as enhance patient well-being. To capture perceptions on 90-day dispensing interval (90D) for ART from the perspective of PLHIV, people on pre-exposure prophylaxis (PrEP), doctors, and pharmacists. Multi-centre observational survey led in France from 16 to 20 October 2020, among doctors agreeing to participate via regional coordinated care organisations for HIV, all PLHIV or people on PrEP consulting these outpatient-clinic doctors, and pharmacists doing ART dispensing. The survey was completed by 220 doctors who saw 1087 people (999 PLHIV; 88 on PrEP) and 176 pharmacists from 55 centres. Among the PLHIV, 855 (85.6%, 95% CI: 83.2%-87.7%) and among the patients on PrEP, 70 (79.5%, 95% CI: 69.6%-87.4%) stated they would be interested in 90D. All in all, patients who were more likely to endorse 90D are those who opt exclusively for hospital dispensing (OR 3.22 [1.57-6.58]) and who rotate between hospital and community pharmacy dispensing (OR 3.29 [1.15-9.32]). Patients who were less likely to endorse 90-D were those who consult in a city located outside the 3 French high HIV prevalence regions (OR 0.66 [0.44-0.99]), receive 2 vs 1 pill QD regimens (OR 0.53 [0.31-0.91]), and anticipate at least one vs no limitation to 90D (OR 0.27 [0.17-0.42]). 90D was perceived as possible by 152 pharmacists (86.4%), including 8 (5%) without restriction, and 219 doctors (99.6%), including 42 (19.2%) regardless of PLHIV's immunovirologic status or social conditions (health insurance coverage, access to housing or accommodation, access to rights, resources). Comparison of the benefits and limitations of a 90-day ART dispensing interval as perceived by PLHIV and people on PrEP, doctors and pharmacists shows that doctors anticipate a higher number of benefits than people on ART and/or pharmacists, chiefly that 90D would be more convenient and create less risk of drug shortages and that patients would gain autonomy and a better quality of life. Pharmacists were found to clearly perceive the economic benefits (90D would be less expensive) but anticipate more drawbacks than doctors and the people on ART themselves: more administrative burdens, more non-dispensing if doses get lost, harder to track adherence a