Serum cobalamin in children with moderate acute malnutrition in Burkina Faso: Secondary analysis of a randomized trial

• Published in: PLoS medicine 2022-03, Vol.19 (3), p.e1003943-e1003943
• Main Authors: Friis, Henrik, Cichon, Bernardette, Fabiansen, Christian, Iuel-Brockdorff, Ann-Sophie, Yaméogo, Charles W, Ritz, Christian, Frikke-Schmidt, Ruth, Briend, André, Michaelsen, Kim F, Christensen, Vibeke B, Filteau, Suzanne, Olsen, Mette F
• Format: Article
• Language: English
• Subjects: Accreditation; Arm circumference; Bioavailability; Biology and Life Sciences; Burkina Faso - epidemiology; Child; Child development; Children; Children & youth; Complications and side effects; Demographic aspects; Dietary Supplements; Edema; Erythropoiesis; Female; Food; Food and nutrition; Hemoglobin; Hemoglobins - metabolism; Humans; Hypersensitivity; Immunoassay; Infant; Malaria; Male; Malnutrition; Malnutrition - epidemiology; Medicine and Health Sciences; Pediatric research; Physical Sciences; Physiological aspects; Proteins; Vitamin B 12; Vitamin B12; Vitamin B12 deficiency; Zea mays
• ISSN: 1549-1676; 1549-1277; 1549-1676
• DOI: 10.1371/journal.pmed.1003943

Among children with moderate acute malnutrition (MAM) the level of serum cobalamin (SC) and effect of food supplements are unknown. We aimed to assess prevalence and correlates of low SC in children with MAM, associations with hemoglobin and development, and effects of food supplements on SC. A randomized 2 × 2 × 3 factorial trial was conducted in Burkina Faso. Children aged 6 to 23 months with MAM received 500 kcal/d as lipid-based nutrient supplement (LNS) or corn-soy blend (CSB), containing dehulled soy (DS) or soy isolate (SI) and 0%, 20%, or 50% of total protein from milk for 3 months. Randomization resulted in baseline equivalence between intervention groups. Data on hemoglobin and development were available at baseline. SC was available at baseline and after 3 and 6 months. SC was available from 1,192 (74.1%) of 1,609 children at baseline. The mean (±SD) age was 12.6 (±5.0) months, and 54% were females. Low mid-upper arm circumference (MUAC;