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SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells
The post-translational modification of DNA damage response proteins with SUMO is an important mechanism to orchestrate a timely and orderly recruitment of repair factors to damage sites. After DNA replication stress and double-strand break formation, a number of repair factors are SUMOylated and int...
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| Published in: | PLoS genetics 2022-03, Vol.18 (3), p.e1009860-e1009860 |
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| creator | Dorison, Hugo Talhaoui, Ibtissam Mazón, Gerard |
| description | The post-translational modification of DNA damage response proteins with SUMO is an important mechanism to orchestrate a timely and orderly recruitment of repair factors to damage sites. After DNA replication stress and double-strand break formation, a number of repair factors are SUMOylated and interact with other SUMOylated factors, including the Yen1 nuclease. Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. Mutations in the motifs that allow SUMO-mediated recruitment of Yen1 impair its ability to resolve DNA intermediates and result in chromosome mis-segregation and increased genome instability. |
| doi_str_mv | 10.1371/journal.pgen.1009860 |
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After DNA replication stress and double-strand break formation, a number of repair factors are SUMOylated and interact with other SUMOylated factors, including the Yen1 nuclease. Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. 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This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. 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After DNA replication stress and double-strand break formation, a number of repair factors are SUMOylated and interact with other SUMOylated factors, including the Yen1 nuclease. Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. 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After DNA replication stress and double-strand break formation, a number of repair factors are SUMOylated and interact with other SUMOylated factors, including the Yen1 nuclease. Yen1 plays a critical role in ensuring genome stability and unperturbed chromosome segregation by removing covalently linked DNA intermediates between sister chromatids that are formed by homologous recombination. Here we show how this important role of Yen1 depends on interactions mediated by non-covalent binding to SUMOylated partners. Mutations in the motifs that allow SUMO-mediated recruitment of Yen1 impair its ability to resolve DNA intermediates and result in chromosome mis-segregation and increased genome instability.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35333860</pmid><doi>10.1371/journal.pgen.1009860</doi><orcidid>https://orcid.org/0000-0002-1431-062X</orcidid><orcidid>https://orcid.org/0000-0002-9791-5666</orcidid><orcidid>https://orcid.org/0000-0001-6359-6559</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Amino acids Biology and life sciences Chromatids Chromosome Segregation - genetics Chromosomes Deoxyribonucleic acid DNA DNA biosynthesis DNA damage DNA repair DNA Repair - genetics Double-strand break repair Endonucleases - genetics Enzymes Genetic aspects Genetic research Genomes Genomic instability Genomic Instability - genetics Holliday Junction Resolvases - genetics Homologous recombination Humans Intermediates Life Sciences Localization Mitosis Mutation Nuclease Nucleases Phosphorylation Physical Sciences Post-translation Post-translational modification Proteins Research and Analysis Methods Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae Proteins - genetics Sister chromatids Small Ubiquitin-Related Modifier Proteins - genetics Small Ubiquitin-Related Modifier Proteins - metabolism Yeast |
| title | SUMO-mediated recruitment allows timely function of the Yen1 nuclease in mitotic cells |
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