Drug therapy problems and predicting factors among ambulatory epileptic patients in Jimma Medical Center, Southwest Ethiopia

• Published in: PloS one 2022-04, Vol.17 (4), p.e0267673-e0267673
• Main Authors: Beyene, Yadeta Babu, Daba, Fekede Bekele, Goro, Kabaye Kumela, Senbeta, Birbirsa Sefera
• Format: Article
• Language: English
• Subjects: Ambulatory care; Antiepileptic agents; Biology and Life Sciences; Care and treatment; Chemotherapy; Cognitive ability; Complications and side effects; Convulsions & seizures; Cross-Sectional Studies; Data collection; Decision making; Dependent variables; Drug dosages; Drug stores; Drug therapy; Drug-Related Side Effects and Adverse Reactions; Drugs; Epilepsy; Epilepsy - drug therapy; Ethiopia - epidemiology; Health care facilities; Health risks; Hospitals; Humans; Independent variables; Interviews; Medical records; Medicine and Health Sciences; Patient outcomes; Patients; People and Places; Pharmacists; Pharmacodynamics; Pharmacokinetics; Pharmacology; Population; Prescription drugs; Public health; Regression analysis; Seizures; Social Sciences; Statistical analysis
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0267673

The care of epileptic patients is complicated by the cognitive adverse effect of the drug, disease, pharmacokinetics, and pharmacodynamics properties of antiepileptic drugs which in turn intensify the risk of drug therapy problems among epileptic patients. To assess drug therapy problems and predicting factors among ambulatory epileptic patients at Jimma University Medical Center, Southwest Ethiopia, from September 2020 to May 2021. A hospital-based prospective observational study was conducted. A semi-structured questionnaire was used to collect data from patients as well as from charts. Drug therapy problems were identified using Cipolle's, Morley, and Strand drug therapy problem identification and classification method. Data were entered into Epi data manager version 4.6 and exported to statistical software package for social science version 23.0 for analysis. Multiplestepwise backward logistic regression analysis was carried out to identify predictors of drug therapy problems. The 95% CI was used to show an association between the dependent and independent variables. P-value < 0.05 was considered as statistically significant. Of the total 320 epileptic patients 224(70.0%) patients had at least one drug therapy problem. A total of 395 drug therapy problems were identified among two hundred twenty-four patients with an average of 1.2 drug therapy problems per patient. The frequently identified drug therapy problems were non-compliance 115(29.11), adverse drug reaction 110(27.84%), and dose too low 103(26%). Getting of a drug by purchasing [AOR = 4.6,95%CI:(2.05-10.7)], poorly involvement of the patients in therapeutic decision making [AOR = 3.02,95%CI:(1.5-6.06)], the number of medications ≥ two [AOR = 5.3,95%CI:(1.2-22.9)] and having had uncontrolled seizure [AOR = 10.9,95%CI:(4.9-24.2)] were independent predictors of drug therapy problems. Drug therapy problems were common among epileptic patients in the study area. Patients who were getting their drugs by purchasing, poorly involved in therapeutic decision making, having had an uncontrolled seizure, and taking two and above drugs were more likely to experience drug therapy problems. Therefore, due attention should be given to patients with the aforementioned problems to decrease the occurrence of drug therapy problems and improve overall outcomes among epileptic patients.