Host diversity and behavior determine patterns of interspecies transmission and geographic diffusion of avian influenza A subtypes among North American wild reservoir species

Wild birds can carry avian influenza viruses (AIV), including those with pandemic or panzootic potential, long distances. Even though AIV has a broad host range, few studies account for host diversity when estimating AIV spread. We analyzed AIV genomic sequences from North American wild birds, inclu...

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Bibliographic Details
Published in:PLoS pathogens 2022-04, Vol.18 (4), p.e1009973
Main Authors: Hicks, Joseph T, Edwards, Kimberly, Qiu, Xueting, Kim, Do-Kyun, Hixson, James E, Krauss, Scott, Webby, Richard J, Webster, Robert G, Bahl, Justin
Format: Article
Language:English
Subjects:
Animals
Animals, Wild
Avian flu
Biodiversity
Biology and Life Sciences
Birds
Breeding
Computer and Information Sciences
Datasets
Disease transmission
Earth Sciences
Ecology and Environmental Sciences
Evolution
Generalized linear models
Genetic aspects
Genetic distance
Genetic diversity
Genotype
Health aspects
Host range
Host-virus relationships
Identification and classification
Influenza
Influenza A
Influenza A virus
Influenza in Birds
Influenza viruses
Medicine and Health Sciences
North America - epidemiology
Pandemics
Phylogenetics
Population
Proteins
Social Sciences
Viruses
Zoonoses
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Summary:Wild birds can carry avian influenza viruses (AIV), including those with pandemic or panzootic potential, long distances. Even though AIV has a broad host range, few studies account for host diversity when estimating AIV spread. We analyzed AIV genomic sequences from North American wild birds, including 303 newly sequenced isolates, to estimate interspecies and geographic viral transition patterns among multiple co-circulating subtypes. Our results show high transition rates within Anseriformes and Charadriiformes, but limited transitions between these orders. Patterns of transition between species were positively associated with breeding habitat range overlap, and negatively associated with host genetic distance. Distance between regions (negative correlation) and summer temperature at origin (positive correlation) were strong predictors of transition between locations. Taken together, this study demonstrates that host diversity and ecology can determine evolutionary processes that underlie AIV natural history and spread. Understanding these processes can provide important insights for effective control of AIV.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1009973