Evaluation of blood cell count parameters as predictors of treatment failure of malaria in Angola: An observational study

Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. A cross-sectional study with a quantitative approach. Of...

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Bibliographic Details
Published in:PloS one 2022-05, Vol.17 (5), p.e0267671-e0267671
Main Authors: Sacomboio, Euclides Nenga Manuel, Dos Santos Sebastião, Cruz, Salvador, Silvana Teresa da Costa, João, Joaquim António, Bapolo, Daisy Viviana Sebastião, Francisco, Ngiambudulu M, Morais, Joana, Valentim, Eduardo Ekundi
Format: Article
Language:English
Subjects:
Anemia
Angola
Antimalarials - therapeutic use
Antimicrobial agents
Artemether
Artemisinin
Biology and Life Sciences
Blood
Blood Cell Count
Blood platelets
Care and treatment
Consent
Cross-Sectional Studies
Disease
Drug resistance
Erythrocytes
Failure
Health aspects
Hematology
Hemoglobin
Hospitalization
Hospitals
Humans
Leukocytes
Leukocytes (neutrophilic)
Lymphocytes
Malaria
Malaria - drug therapy
Malaria, Falciparum - drug therapy
Male
Medicine and Health Sciences
Mortality
Neutrophils
Observational studies
Parameters
Parasitemia
Parasitemia - drug therapy
Patient outcomes
Patients
Therapy
Thrombocytopenia
Treatment Failure
Urban areas
Vector-borne diseases
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Summary:Despite the guidelines provided by the World Health Organization for the treatment of malaria, treatment failure occurs in many hospitalized patients. Evaluate whether blood cell count parameters may serve as predictors for malaria treatment. A cross-sectional study with a quantitative approach. Of the 219 patients, 21.5% showed failure to antimalarial treatment, Patient with 21 and 40 years (72.6%), male (53.4%), from peri-urban area (47.5%), with high parasitemia (59.8%), treated with Arthemeter (90.9%) and the mortality were 5.9%. Significant associations were observed between occupation, level of parasitemia and outcome with resistance to antimalarial treatment (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0267671