Efficacy versus abundancy: Comparing vaccination schemes

We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and rate of deployment of low efficacy vaccines lowers the cumul...

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Bibliographic Details
Published in:PloS one 2022-05, Vol.17 (5), p.e0267840-e0267840
Main Authors: El Deeb, Omar, Jalloul, Maya
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Coronaviruses
COVID-19 vaccines
Disease transmission
Economic conditions
Epidemics
Evaluation
Fatalities
Herd immunity
Immunity, Herd
Infections
Infectious diseases
Initial conditions
Management
Medicine and Health Sciences
Ordinary differential equations
Pandemics
Population
Public health
R&D
Research & development
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccine efficacy
Vaccines
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Description
Summary:We introduce a novel compartmental model accounting for the effects of vaccine efficacy, deployment rates and timing of initiation of deployment. We simulate different scenarios and initial conditions, and we find that higher abundancy and rate of deployment of low efficacy vaccines lowers the cumulative number of deaths in comparison to slower deployment of high efficacy vaccines. We also forecast that, at the same daily deployment rate, the earlier introduction of vaccination schemes with lower efficacy would also lower the number of deaths with respect to a delayed introduction of high efficacy vaccines, which can however, still achieve lower numbers of infections and better herd immunity.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0267840