Gestational age, birth weight, and perinatal complications in mothers with diabetes and impaired glucose tolerance: Japan Environment and Children's Study cohort

We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort between 2011 and 2014. We included 67 mot...

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Bibliographic Details
Published in:PloS one 2022-06, Vol.17 (6), p.e0269610-e0269610
Main Authors: Yokomichi, Hiroshi, Mochizuki, Mie, Shinohara, Ryoji, Kushima, Megumi, Horiuchi, Sayaka, Kojima, Reiji, Ooka, Tadao, Akiyama, Yuka, Miyake, Kunio, Otawa, Sanae, Yamagata, Zentaro
Format: Article
Language:English
Subjects:
Age
Biology and Life Sciences
Birth size
Birth weight
Children
Complications
Complications and side effects
Congenital diseases
Diabetes
Diabetes mellitus
Diabetes mellitus (insulin dependent)
Diabetes mellitus (non-insulin dependent)
Diagnosis
Evaluation
Gestational age
Gestational diabetes
Glucose
Glucose tolerance
Health risks
Hypertension
Jaundice
Medicine and Health Sciences
Mothers
Neonates
Newborn babies
Physical Sciences
Placenta
Plasma
Pregnancy
Pregnancy, Complications of
Premature birth
Questionnaires
Risk assessment
Screening
Womens health
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Summary:We aimed to determine the risk of perinatal complications during delivery in mothers with non-normal glucose tolerance in a large Japanese birth cohort. We analysed data of 24,295 neonate-mother pairs in the Japan Environment and Children's Study cohort between 2011 and 2014. We included 67 mothers with type 1 diabetes, 102 with type 2 diabetes (determined by questionnaire), 2,045 with gestational diabetes (determined by diagnosis), and 2,949 with plasma glucose levels ≥140 mg/dL (shown by a screening test for gestational diabetes). Gestational age, birth weight, placental weight, and proportions of preterm birth, and labour and neonatal complications at delivery in mothers with diabetes were compared with those in mothers with normal glucose tolerance. Mean gestational age was shorter in mothers with any type of diabetes than in mothers without diabetes. Birth weight tended to be heavier in mothers with type 1 diabetes, and placental weight was significantly heavier in mothers with type 1 and gestational diabetes and elevated plasma glucose levels (all p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0269610