Clinical and survival differences during separate COVID-19 surges: Investigating the impact of the Sars-CoV-2 alpha variant in critical care patients

A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing emerging variants of SARS-CoV-2, such as B.1.1.7. We compared ventilatory parameters, biochemical and physiological data and mortality between...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0269244-e0269244
Main Authors: Ritchie, Andrew I, Kadwani, Owais, Saleh, Dina, Baharlo, Behrad, Broomhead, Lesley R, Randell, Paul, Waheed, Umeer, Templeton, Maie, Brown, Elizabeth, Stümpfle, Richard, Patel, Parind, Brett, Stephen J, Soni, Sanooj
Format: Article
Language:English
Subjects:
Biology and life sciences
Biomarkers
Care and treatment
Coronaviruses
COVID-19
Critical care medicine
Epidemics
Health risks
Immunology
Medicine and Health Sciences
Methods
Mortality
Mortality risk
Pandemics
Patients
Physiology
Research and Analysis Methods
Severe acute respiratory syndrome
Severe acute respiratory syndrome coronavirus 2
Social aspects
Statistical analysis
Surges
Tertiary
United Kingdom
Ventilation
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Summary:A number of studies have highlighted physiological data from the first surge in critically unwell Covid-19 patients but there is a paucity of data describing emerging variants of SARS-CoV-2, such as B.1.1.7. We compared ventilatory parameters, biochemical and physiological data and mortality between the first and second COVID-19 surges in the United Kingdom, where distinct variants of SARS-CoV-2 were the dominant stain. We performed a retrospective cohort study investigating critically unwell patients admitted with COVID-19 across three tertiary regional ICUs in London, UK. Of 1782 adult ICU patients screened, 330 intubated and ventilated patients diagnosed with COVID-19 were included. In the second wave where B.1.1.7 variant was the dominant strain, patients were had increased severity of ARDS whilst compliance was greater (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0269244