Association of hepatitis C virus infection status and genotype with kidney disease risk: A population-based cross-sectional study

Whether there is difference in kidney disease risk between chronic hepatitis C virus (HCV) infection and resolved HCV infection remains inconclusive. Additionally, the impact of different HCV genotypes on kidney disease risk is relatively unknown. Accordingly, we conducted a population-based cross-s...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0271197-e0271197
Main Authors: Chen, Yi-Chia, Wang, Hung-Wei, Huang, Yun-Ting, Jiang, Ming-Yan
Format: Article
Language:English
Subjects:
Albumins
Algorithms
Antibodies
Antigens
Biology and life sciences
Body mass index
Cardiovascular disease
Chronic infection
Complications and side effects
Creatinine
Cross-sectional studies
Diabetes
Ethnicity
Genetic aspects
Genotype
Genotype & phenotype
Genotypes
Glomerular filtration rate
Health aspects
Health risks
Hepatitis
Hepatitis B
Hepatitis C
Hepatitis C virus
HIV
Human immunodeficiency virus
Hypertension
Immunoassay
Infections
Kidney diseases
Kidneys
Medicine and health sciences
Nutrition
Patient outcomes
Population
Population studies
Population-based studies
Regression analysis
Risk
Risk factors
Viruses
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Summary:Whether there is difference in kidney disease risk between chronic hepatitis C virus (HCV) infection and resolved HCV infection remains inconclusive. Additionally, the impact of different HCV genotypes on kidney disease risk is relatively unknown. Accordingly, we conducted a population-based cross-sectional study to investigate the association of HCV infection status and genotype on kidney disease risk. The study population were adult participants of 1999-2018 National Health and Nutrition Examination Survey in the United States. Chronic and resolved infection were defined as HCV seropositivity with and without detectable HCV RNA, respectively. HCV genotypes were classified into genotype 1, genotype 2, and other genotypes. Prevalent estimated glomerular filtration rate < 60 ml/min/1.73 m.sup.2 or urinary albumin creatinine ratio [greater than or equal to] 30 mg/g was defined as kidney disease. The average age of study population (n = 44,998) was 46.7±17.0 years with 49.8% being males. Compared with individuals without HCV infection (n = 44,157), those with resolved (n = 255) or chronic HCV infection (n = 586) had higher prevalence of kidney disease: 14.8%, 23.5%, and 20.1%, respectively (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271197