Clinical impact of statin intensity according to age in patients with acute myocardial infarction

The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI). Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-06, Vol.17 (6), p.e0269301-e0269301
Main Authors: Lee, Kyusup, Lee, Myunhee, Kim, Dae-Won, Kim, Jinseob, Lim, Sungmin, Choo, Eun Ho, Kim, Chan Joon, Park, Chul Soo, Kim, Hee Yeol, Yoo, Ki-Dong, Jeon, Doo Soo, Chang, Kiyuk, Youn, Ho Joong, Chung, Wook-Sung, Kim, Min Chul, Jeong, Myung Ho, Ahn, Youngkeun, Kwon, Jongbum, Park, Mahn-Won
Format: Article
Language:English
Subjects:
Age
Angioplasty
Biology and Life Sciences
Blood vessels
Cardiology
Cardiovascular disease
Clinical outcomes
Complications and side effects
Confidence intervals
Drug delivery
Drug dosages
Drug therapy
Heart attack
Heart attacks
Hospitals
Implants
Medicine and Health Sciences
Myocardial infarction
Older people
Patient outcomes
Patients
Population studies
Regression analysis
Statins
Stents
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953
cites cdi_FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953
container_end_page e0269301
container_issue 6
container_start_page e0269301
container_title PloS one
container_volume 17
creator Lee, Kyusup
Lee, Myunhee
Kim, Dae-Won
Kim, Jinseob
Lim, Sungmin
Choo, Eun Ho
Kim, Chan Joon
Park, Chul Soo
Kim, Hee Yeol
Yoo, Ki-Dong
Jeon, Doo Soo
Chang, Kiyuk
Youn, Ho Joong
Chung, Wook-Sung
Kim, Min Chul
Jeong, Myung Ho
Ahn, Youngkeun
Kwon, Jongbum
Park, Mahn-Won
description The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI). Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to-moderate-intensity statin in younger (
doi_str_mv 10.1371/journal.pone.0269301
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2687698329</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A707221199</galeid><doaj_id>oai_doaj_org_article_338c6c3016174c8ab2ab1b3ecd0dd953</doaj_id><sourcerecordid>A707221199</sourcerecordid><originalsourceid>FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953</originalsourceid><addsrcrecordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTJu2NsAx-DCws-HUbTpO0kyFNuk2qzr83dbrLVPZCcpGQPOc9yZtzkuQ5RmtMGH63d-Ngwax7Z9UaZbQiCD9IznFFshXNEHl4sj5Lnni_R6ggJaWPkzNSMJRTgs4T2BhttQCT6q4HEVLXpD5A0DbVNijrdTikIIQbpLZtGlwKrYpHaR8ZZYNPf-mwi8QYVNodnIAITmq2gUEE7ezT5FEDxqtn83yRfP_44dvm8-rq-tN2c3m1ErTKwkpioiQF3DRC1RLyEhUgEUMI5UjghmLB6lrmqsxyVhAEhNZ5VReyETineVWQi-TlUbc3zvPZHc8zWjJalSSrIrE9EtLBnveD7mA4cAea_91wQ8thCFoYxQkpBRXRUYpZLkqoM6hxTZSQSMqYLGq9n7ONdaekiFYMYBaiyxOrd7x1P3mVIUTySeDNLDC4m1H5wDvthTIGrHLjdG_GCkaqCkX01T_o_a-bqRbiA6L_LuYVkyi_ZIhlGcbVRK3voeKQqtMillKj4_4i4O0iIDJB_Q4tjN7z7dcv_89e_1iyr0_YnQITdt6ZcSoZvwTzIygG5_2gmjuTMeJTJ9y6wadO4HMnxLAXpx90F3Rb-uQPJgkEIw</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2687698329</pqid></control><display><type>article</type><title>Clinical impact of statin intensity according to age in patients with acute myocardial infarction</title><source>ProQuest - Publicly Available Content Database</source><source>PubMed Central</source><creator>Lee, Kyusup ; Lee, Myunhee ; Kim, Dae-Won ; Kim, Jinseob ; Lim, Sungmin ; Choo, Eun Ho ; Kim, Chan Joon ; Park, Chul Soo ; Kim, Hee Yeol ; Yoo, Ki-Dong ; Jeon, Doo Soo ; Chang, Kiyuk ; Youn, Ho Joong ; Chung, Wook-Sung ; Kim, Min Chul ; Jeong, Myung Ho ; Ahn, Youngkeun ; Kwon, Jongbum ; Park, Mahn-Won</creator><contributor>Widmer, R. Jay</contributor><creatorcontrib>Lee, Kyusup ; Lee, Myunhee ; Kim, Dae-Won ; Kim, Jinseob ; Lim, Sungmin ; Choo, Eun Ho ; Kim, Chan Joon ; Park, Chul Soo ; Kim, Hee Yeol ; Yoo, Ki-Dong ; Jeon, Doo Soo ; Chang, Kiyuk ; Youn, Ho Joong ; Chung, Wook-Sung ; Kim, Min Chul ; Jeong, Myung Ho ; Ahn, Youngkeun ; Kwon, Jongbum ; Park, Mahn-Won ; Widmer, R. Jay</creatorcontrib><description>The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI). Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to-moderate-intensity statin in younger (&lt;75 years old) and elderly (≥75 years old) patients. Of 10,719 patients, we included 8,096 patients treated with drug-eluting stents. All patients were classified into high-intensity versus low-to-moderate-intensity statin group according to statin type and dose at discharge. The primary end point was target-vessel failure (TVF), a composite of cardiovascular death, target-vessel MI, or target-lesion revascularization (TLR) from 1 month to 12 months after index PCI. In younger patients, high-intensity statin showed the better clinical outcomes than low-to-moderate-intensity statin (TVF: 79 [5.4%] vs. 329 [6.8%], adjusted hazard ratio [aHR] 0.76; 95% confidence interval [CI] 0.59-0.99; P = 0.038). However, in elderly patients, the incidence rates of the adverse clinical outcomes were similar between two statin-intensity groups (TVF: 38 [11.4%] vs. 131 [10.6%], aHR 1.1; 95% CI 0.76-1.59; P = 0.63). In this AMI cohort underwent PCI, high-intensity statin showed the better 1-year clinical outcomes than low-to-moderate-intensity statin in younger patients. Meanwhile, the incidence rates of adverse clinical events between high- and low-to-moderate-intensity statin were not statistically different in elderly patients. Further randomized study with large elderly population is warranted.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0269301</identifier><identifier>PMID: 35704630</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Age ; Angioplasty ; Biology and Life Sciences ; Blood vessels ; Cardiology ; Cardiovascular disease ; Clinical outcomes ; Complications and side effects ; Confidence intervals ; Drug delivery ; Drug dosages ; Drug therapy ; Heart attack ; Heart attacks ; Hospitals ; Implants ; Medicine and Health Sciences ; Myocardial infarction ; Older people ; Patient outcomes ; Patients ; Population studies ; Regression analysis ; Statins ; Stents</subject><ispartof>PloS one, 2022-06, Vol.17 (6), p.e0269301-e0269301</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Lee et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Lee et al 2022 Lee et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953</citedby><cites>FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953</cites><orcidid>0000-0003-0149-5503 ; 0000-0001-6026-1702 ; 0000-0001-5425-1102</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2687698329/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2687698329?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35704630$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Widmer, R. Jay</contributor><creatorcontrib>Lee, Kyusup</creatorcontrib><creatorcontrib>Lee, Myunhee</creatorcontrib><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Kim, Jinseob</creatorcontrib><creatorcontrib>Lim, Sungmin</creatorcontrib><creatorcontrib>Choo, Eun Ho</creatorcontrib><creatorcontrib>Kim, Chan Joon</creatorcontrib><creatorcontrib>Park, Chul Soo</creatorcontrib><creatorcontrib>Kim, Hee Yeol</creatorcontrib><creatorcontrib>Yoo, Ki-Dong</creatorcontrib><creatorcontrib>Jeon, Doo Soo</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Youn, Ho Joong</creatorcontrib><creatorcontrib>Chung, Wook-Sung</creatorcontrib><creatorcontrib>Kim, Min Chul</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Ahn, Youngkeun</creatorcontrib><creatorcontrib>Kwon, Jongbum</creatorcontrib><creatorcontrib>Park, Mahn-Won</creatorcontrib><title>Clinical impact of statin intensity according to age in patients with acute myocardial infarction</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI). Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to-moderate-intensity statin in younger (&lt;75 years old) and elderly (≥75 years old) patients. Of 10,719 patients, we included 8,096 patients treated with drug-eluting stents. All patients were classified into high-intensity versus low-to-moderate-intensity statin group according to statin type and dose at discharge. The primary end point was target-vessel failure (TVF), a composite of cardiovascular death, target-vessel MI, or target-lesion revascularization (TLR) from 1 month to 12 months after index PCI. In younger patients, high-intensity statin showed the better clinical outcomes than low-to-moderate-intensity statin (TVF: 79 [5.4%] vs. 329 [6.8%], adjusted hazard ratio [aHR] 0.76; 95% confidence interval [CI] 0.59-0.99; P = 0.038). However, in elderly patients, the incidence rates of the adverse clinical outcomes were similar between two statin-intensity groups (TVF: 38 [11.4%] vs. 131 [10.6%], aHR 1.1; 95% CI 0.76-1.59; P = 0.63). In this AMI cohort underwent PCI, high-intensity statin showed the better 1-year clinical outcomes than low-to-moderate-intensity statin in younger patients. Meanwhile, the incidence rates of adverse clinical events between high- and low-to-moderate-intensity statin were not statistically different in elderly patients. Further randomized study with large elderly population is warranted.</description><subject>Age</subject><subject>Angioplasty</subject><subject>Biology and Life Sciences</subject><subject>Blood vessels</subject><subject>Cardiology</subject><subject>Cardiovascular disease</subject><subject>Clinical outcomes</subject><subject>Complications and side effects</subject><subject>Confidence intervals</subject><subject>Drug delivery</subject><subject>Drug dosages</subject><subject>Drug therapy</subject><subject>Heart attack</subject><subject>Heart attacks</subject><subject>Hospitals</subject><subject>Implants</subject><subject>Medicine and Health Sciences</subject><subject>Myocardial infarction</subject><subject>Older people</subject><subject>Patient outcomes</subject><subject>Patients</subject><subject>Population studies</subject><subject>Regression analysis</subject><subject>Statins</subject><subject>Stents</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk12L1DAUhoso7rr6D0QLgujFjEnTJu2NsAx-DCws-HUbTpO0kyFNuk2qzr83dbrLVPZCcpGQPOc9yZtzkuQ5RmtMGH63d-Ngwax7Z9UaZbQiCD9IznFFshXNEHl4sj5Lnni_R6ggJaWPkzNSMJRTgs4T2BhttQCT6q4HEVLXpD5A0DbVNijrdTikIIQbpLZtGlwKrYpHaR8ZZYNPf-mwi8QYVNodnIAITmq2gUEE7ezT5FEDxqtn83yRfP_44dvm8-rq-tN2c3m1ErTKwkpioiQF3DRC1RLyEhUgEUMI5UjghmLB6lrmqsxyVhAEhNZ5VReyETineVWQi-TlUbc3zvPZHc8zWjJalSSrIrE9EtLBnveD7mA4cAea_91wQ8thCFoYxQkpBRXRUYpZLkqoM6hxTZSQSMqYLGq9n7ONdaekiFYMYBaiyxOrd7x1P3mVIUTySeDNLDC4m1H5wDvthTIGrHLjdG_GCkaqCkX01T_o_a-bqRbiA6L_LuYVkyi_ZIhlGcbVRK3voeKQqtMillKj4_4i4O0iIDJB_Q4tjN7z7dcv_89e_1iyr0_YnQITdt6ZcSoZvwTzIygG5_2gmjuTMeJTJ9y6wadO4HMnxLAXpx90F3Rb-uQPJgkEIw</recordid><startdate>20220615</startdate><enddate>20220615</enddate><creator>Lee, Kyusup</creator><creator>Lee, Myunhee</creator><creator>Kim, Dae-Won</creator><creator>Kim, Jinseob</creator><creator>Lim, Sungmin</creator><creator>Choo, Eun Ho</creator><creator>Kim, Chan Joon</creator><creator>Park, Chul Soo</creator><creator>Kim, Hee Yeol</creator><creator>Yoo, Ki-Dong</creator><creator>Jeon, Doo Soo</creator><creator>Chang, Kiyuk</creator><creator>Youn, Ho Joong</creator><creator>Chung, Wook-Sung</creator><creator>Kim, Min Chul</creator><creator>Jeong, Myung Ho</creator><creator>Ahn, Youngkeun</creator><creator>Kwon, Jongbum</creator><creator>Park, Mahn-Won</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0149-5503</orcidid><orcidid>https://orcid.org/0000-0001-6026-1702</orcidid><orcidid>https://orcid.org/0000-0001-5425-1102</orcidid></search><sort><creationdate>20220615</creationdate><title>Clinical impact of statin intensity according to age in patients with acute myocardial infarction</title><author>Lee, Kyusup ; Lee, Myunhee ; Kim, Dae-Won ; Kim, Jinseob ; Lim, Sungmin ; Choo, Eun Ho ; Kim, Chan Joon ; Park, Chul Soo ; Kim, Hee Yeol ; Yoo, Ki-Dong ; Jeon, Doo Soo ; Chang, Kiyuk ; Youn, Ho Joong ; Chung, Wook-Sung ; Kim, Min Chul ; Jeong, Myung Ho ; Ahn, Youngkeun ; Kwon, Jongbum ; Park, Mahn-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Age</topic><topic>Angioplasty</topic><topic>Biology and Life Sciences</topic><topic>Blood vessels</topic><topic>Cardiology</topic><topic>Cardiovascular disease</topic><topic>Clinical outcomes</topic><topic>Complications and side effects</topic><topic>Confidence intervals</topic><topic>Drug delivery</topic><topic>Drug dosages</topic><topic>Drug therapy</topic><topic>Heart attack</topic><topic>Heart attacks</topic><topic>Hospitals</topic><topic>Implants</topic><topic>Medicine and Health Sciences</topic><topic>Myocardial infarction</topic><topic>Older people</topic><topic>Patient outcomes</topic><topic>Patients</topic><topic>Population studies</topic><topic>Regression analysis</topic><topic>Statins</topic><topic>Stents</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lee, Kyusup</creatorcontrib><creatorcontrib>Lee, Myunhee</creatorcontrib><creatorcontrib>Kim, Dae-Won</creatorcontrib><creatorcontrib>Kim, Jinseob</creatorcontrib><creatorcontrib>Lim, Sungmin</creatorcontrib><creatorcontrib>Choo, Eun Ho</creatorcontrib><creatorcontrib>Kim, Chan Joon</creatorcontrib><creatorcontrib>Park, Chul Soo</creatorcontrib><creatorcontrib>Kim, Hee Yeol</creatorcontrib><creatorcontrib>Yoo, Ki-Dong</creatorcontrib><creatorcontrib>Jeon, Doo Soo</creatorcontrib><creatorcontrib>Chang, Kiyuk</creatorcontrib><creatorcontrib>Youn, Ho Joong</creatorcontrib><creatorcontrib>Chung, Wook-Sung</creatorcontrib><creatorcontrib>Kim, Min Chul</creatorcontrib><creatorcontrib>Jeong, Myung Ho</creatorcontrib><creatorcontrib>Ahn, Youngkeun</creatorcontrib><creatorcontrib>Kwon, Jongbum</creatorcontrib><creatorcontrib>Park, Mahn-Won</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Opposing Viewpoints Resource Center</collection><collection>Gale In Context: Science</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>ProQuest Nursing and Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies &amp; Aerospace Database‎ (1962 - current)</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>https://resources.nclive.org/materials</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>ProQuest - Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lee, Kyusup</au><au>Lee, Myunhee</au><au>Kim, Dae-Won</au><au>Kim, Jinseob</au><au>Lim, Sungmin</au><au>Choo, Eun Ho</au><au>Kim, Chan Joon</au><au>Park, Chul Soo</au><au>Kim, Hee Yeol</au><au>Yoo, Ki-Dong</au><au>Jeon, Doo Soo</au><au>Chang, Kiyuk</au><au>Youn, Ho Joong</au><au>Chung, Wook-Sung</au><au>Kim, Min Chul</au><au>Jeong, Myung Ho</au><au>Ahn, Youngkeun</au><au>Kwon, Jongbum</au><au>Park, Mahn-Won</au><au>Widmer, R. Jay</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical impact of statin intensity according to age in patients with acute myocardial infarction</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2022-06-15</date><risdate>2022</risdate><volume>17</volume><issue>6</issue><spage>e0269301</spage><epage>e0269301</epage><pages>e0269301-e0269301</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>The available data are not sufficient to understand the clinical impact of statin intensity in elderly patients who undergo percutaneous coronary intervention (PCI) due to acute myocardial infarction (AMI). Using the COREA-AMI registry, we sought to compare the clinical impact of high- versus low-to-moderate-intensity statin in younger (&lt;75 years old) and elderly (≥75 years old) patients. Of 10,719 patients, we included 8,096 patients treated with drug-eluting stents. All patients were classified into high-intensity versus low-to-moderate-intensity statin group according to statin type and dose at discharge. The primary end point was target-vessel failure (TVF), a composite of cardiovascular death, target-vessel MI, or target-lesion revascularization (TLR) from 1 month to 12 months after index PCI. In younger patients, high-intensity statin showed the better clinical outcomes than low-to-moderate-intensity statin (TVF: 79 [5.4%] vs. 329 [6.8%], adjusted hazard ratio [aHR] 0.76; 95% confidence interval [CI] 0.59-0.99; P = 0.038). However, in elderly patients, the incidence rates of the adverse clinical outcomes were similar between two statin-intensity groups (TVF: 38 [11.4%] vs. 131 [10.6%], aHR 1.1; 95% CI 0.76-1.59; P = 0.63). In this AMI cohort underwent PCI, high-intensity statin showed the better 1-year clinical outcomes than low-to-moderate-intensity statin in younger patients. Meanwhile, the incidence rates of adverse clinical events between high- and low-to-moderate-intensity statin were not statistically different in elderly patients. Further randomized study with large elderly population is warranted.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35704630</pmid><doi>10.1371/journal.pone.0269301</doi><tpages>e0269301</tpages><orcidid>https://orcid.org/0000-0003-0149-5503</orcidid><orcidid>https://orcid.org/0000-0001-6026-1702</orcidid><orcidid>https://orcid.org/0000-0001-5425-1102</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2022-06, Vol.17 (6), p.e0269301-e0269301
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2687698329
source ProQuest - Publicly Available Content Database; PubMed Central
subjects Age
Angioplasty
Biology and Life Sciences
Blood vessels
Cardiology
Cardiovascular disease
Clinical outcomes
Complications and side effects
Confidence intervals
Drug delivery
Drug dosages
Drug therapy
Heart attack
Heart attacks
Hospitals
Implants
Medicine and Health Sciences
Myocardial infarction
Older people
Patient outcomes
Patients
Population studies
Regression analysis
Statins
Stents
title Clinical impact of statin intensity according to age in patients with acute myocardial infarction
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T05%3A57%3A02IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Clinical%20impact%20of%20statin%20intensity%20according%20to%20age%20in%20patients%20with%20acute%20myocardial%20infarction&rft.jtitle=PloS%20one&rft.au=Lee,%20Kyusup&rft.date=2022-06-15&rft.volume=17&rft.issue=6&rft.spage=e0269301&rft.epage=e0269301&rft.pages=e0269301-e0269301&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0269301&rft_dat=%3Cgale_plos_%3EA707221199%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c692t-d13ed6a1ffcebda4805ad0700040c1f61c7bbd4e8247530a36b49b5dfc1464953%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2687698329&rft_id=info:pmid/35704630&rft_galeid=A707221199&rfr_iscdi=true