Temporal changes in spike IgG levels after two doses of BNT162b2 vaccine in Japanese healthcare workers: Do spike IgG levels at 3 months predict levels 6 or 8 months after vaccination?

Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG...

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Bibliographic Details
Published in:PloS one 2022-06, Vol.17 (6), p.e0263486-e0263486
Main Authors: Takeuchi, Masaaki, Esaki, Akina, Higa, Yukie, Nakazono, Akemi
Format: Article
Language:English
Subjects:
Antibodies
Architects
Biology and Life Sciences
Coronaviruses
Correlation
COVID-19
COVID-19 vaccines
Health aspects
Health care
Immune status
Immunoglobulin G
Infections
Laboratories
Medical personnel
Medicine and Health Sciences
Proteins
Regression analysis
Severe acute respiratory syndrome coronavirus 2
Vaccination
Vaccines
Viral diseases
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Summary:Accurate timing of BNT162b2 boosters to prevent breakthrough infections of coronavirus disease 2019 (COVID-19) requires reliable estimates of immune status. We hypothesized that spike IgG levels at 3 months after two doses of the BNT162b2 vaccine might predict subsequent spike IgG levels. Spike IgG levels were tested at 3, 6, and 8 months after the second dose of the BNT162b2 vaccine in 251 Japanese health care workers (median age: 39 years, female: 187). We conclude that predictive formulae using spike IgG levels at 3 months after two-dose vaccination with BNT162b2 reliably estimate subsequent spike IgG levels up to 8 months and provide useful information in terms of vaccination booster timing.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0263486