Factors associated with vaccination against Covid-19 in pregnant and hospitalized postpartum women: A retrospective cohort study

• Published in: PloS one 2022-06, Vol.17 (6), p.e0269091-e0269091
• Main Authors: de Andrade Pereira Silva, Marcela, Ribeiro, Helena Fiats, Oliveira, Rosana Rosseto de, Pelloso, Fernando Castilho, Pujals, Constanza, Pedroso, Raíssa Bocchi, Carvalho, Maria Dalva de Barros, Pelloso, Sandra Marisa
• Format: Article
• Language: English
• Subjects: Biology and Life Sciences; Cohort analysis; Comorbidity; Continuity (mathematics); Coronaviruses; COVID-19; COVID-19 vaccines; Epidemiology; Fatalities; Health aspects; Health risks; Influenza; Information systems; Mathematical analysis; Mechanical ventilation; Medicine and Health Sciences; People and places; Population studies; Postpartum; Pregnancy; Pregnant women; Public health; Regression analysis; Respiratory diseases; Severe acute respiratory syndrome; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Statistical analysis; Vaccination; Ventilation; Viral diseases; Womens health
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0269091

To analyze the characteristics associated with vaccination against Covid-19 in pregnant and postpartum women with Severe Acute Respiratory Syndrome in Brazil and to investigate a possible association between vaccination and the clinical course and outcome of the disease. Retrospective cohort study of hospitalized pregnant and postpartum women diagnosed with Severe Acute Respiratory Syndrome (SARS) by SARS-CoV-2, presenting onset of signs and symptoms between May and October 2021. Secondary data were used, available in the Influenza Epidemiological Surveillance Information System (SIVEP-Gripe). Data were analyzed using the SPSS statistical program, medians were applied to present continuous variables and frequencies, and proportions were calculated for categorical variables, using logistic and multivariate regression analysis. The final study population included 3,585 pregnant and postpartum women, of whom 596 (16.6) were vaccinated: 443 (74.3%) received one dose and 153 (25.7%) received two doses. They were factors associated with non-vaccination against Covid-19 age ≤ 19 anos (OR: 2.57; IC95% 1.40;4.71), non-white women (OR: 1.34; IC95% 1.07;1.67) and those who required ventilatory support (OR: 1.51; IC95% 1.19;1.90) and invasive ventilation (OR: 2.05; IC95% 1.37;3.08). On the other hand, vaccination was associated with advanced maternal age (OR: 0.60; IC95% 0.48;0.76), presence of comorbidities (OR: 0.57; IC95% 0.45;0.72) and loss of taste (OR: 0.63; IC95% 0.48;0.82). Demographic, ethnic-racial and clinical characteristics were associated with the vaccination status of pregnant and postpartum women with SARS by SARS-CoV-2 in Brazil. Vaccination against Covid-19 in the obstetric population has already shown positive results in the evolution of severe cases, which reiterates its importance. It is essential that health services advance vaccination against Covid-19 in the obstetric population, especially adolescentes and non-white women.