Association between MTHFR (677C>T and 1298A>C) polymorphisms and psychiatric disorder: A meta-analysis

Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrog...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0271170-e0271170
Main Authors: Meng, Xinyao, Zheng, Ji-long, Sun, Mao-ling, Lai, Hai-yun, Wang, Bao-jie, Yao, Jun, Wang, Hongbo
Format: Article
Language:English
Subjects:
Analysis
Attention deficit hyperactivity disorder
Biology and Life Sciences
Bipolar disorder
Confidence intervals
Criteria
Disease
DNA methylation
Enzymes
Epidemiology
Etiology
Folic acid
Gene polymorphism
Genetic analysis
Genetic aspects
Genetic polymorphisms
Genotype & phenotype
Hyperactivity
Medicine and Health Sciences
Mental disorders
Mental illness
Meta-analysis
Methylenetetrahydrofolate reductase
Mutation
Physical Sciences
Polymorphism
Properties
Reductases
Research and Analysis Methods
Schizophrenia
Sensitivity analysis
Statistical analysis
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Summary:Recent studies showed that genetic polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) is related to attention-deficit hyperactivity disorder (ADHD), bipolar disorder (BD) and schizophrenia (SCZ). However, no consistent conclusion has been determined. This meta-analysis aims to interrogate the relationship between MTHFR gene polymorphisms (677C>T and 1298A>C) and the occurrence of ADHD, BD and SCZ. We retrieved case-control studies that met the inclusion criteria from the PubMed database. Associations between MTHFR polymorphisms (677C>T and 1298A>C) and ADHD, BD and SCZ were measured by means of odds ratios (ORs) using a random effects model and 95% confidence intervals (CIs). Additionally, sensitivity analysis and publication bias were performed. After inclusion criteria were met, a total of five studies with ADHD including 434 cases and 670 controls, 18 studies with BD including 4167 cases and 5901 controls and 44 studies with SCZ including 16,098 cases and 19913 controls were finally included in our meta-analysis. Overall, our meta-analytical results provided evidence that the MTHFR 677C>T was associated with occurrence of BD and SCZ, while the 1298A>C polymorphism was related to ADHD and BD, and additionally the sensitivity analysis indicated these results were stable and reliable. This may provide useful information for relevant studies on the etiology of psychiatric disorders.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271170