PARP14: A key ADP-ribosylating protein in host-virus interactions?

• Published in: PLoS pathogens 2022-06, Vol.18 (6), p.e1010535-e1010535
• Main Authors: Parthasarathy, Srivatsan, Fehr, Anthony R
• Format: Article
• Language: English
• Subjects: Adenosine Diphosphate; ADP Ribose Transferases - metabolism; Apoptosis; Bacterial infections; Biology and Life Sciences; Cancer; Cell cycle; Coronaviruses; Cytokines; DNA repair; Epithelial cells; Epithelium; Gene expression; Genes; Host Microbial Interactions; Immune response; Infections; Interleukin 4; Localization; Lymphoma; Macrophages; Medicine and Health Sciences; Pathogens; Pearls; Phosphorylation; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerases - metabolism; Positive selection; Proteins; Severe acute respiratory syndrome coronavirus 2; Signal transduction; Signaling; siRNA; Stat1 protein; Stat6 protein; Viral infections; Viruses; γ-Interferon
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1010535

PARP14 selectively binds to STAT6 and promotes the expression of IL-4–regulated genes [9]. Since this original discovery, PARP14’s ability to regulate IL-4 signaling pathway has been implicated in several diseases. [...]the impact of PARP14 on STAT1 signaling and ISG expression in M0 macrophages or epithelial cells, as demonstrated in M1 macrophages following IFNγ treatment [19], has not been addressed. [...]research on this topic is necessary. [...]PARP14 was also identified as one of the 5 human PARP genes that has evolved under positive selection, a trait common to genes that are usually involved in immune response to pathogens [24]. [...]we demonstrated that siRNA knockdown of PARP14 mildly enhanced the replication of MHV N1347A, but not WT virus.