OLA-1, an Obg-like ATPase, integrates hunger with temperature information in sensory neurons in C. elegans

Animals detect changes in both their environment and their internal state and modify their behavior accordingly. Yet, it remains largely to be clarified how information of environment and internal state is integrated and how such integrated information modifies behavior. Well-fed C. elegans migrates...

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Bibliographic Details
Published in:PLoS genetics 2022-06, Vol.18 (6), p.e1010219-e1010219
Main Authors: Aoki, Ichiro, Jurado, Paola, Nawa, Kanji, Kondo, Rumi, Yamashiro, Riku, Matsuyama, Hironori J, Ferrer, Isidre, Nakano, Shunji, Mori, Ikue
Format: Article
Language:English
Subjects:
Adenosine Triphosphatases - genetics
Animals
Biology and Life Sciences
Caenorhabditis elegans - genetics
Caenorhabditis elegans Proteins - genetics
Food
Gene expression
Hunger
Kinases
Nervous system
Neurons
Neurotransmitter release
Physical Sciences
Research and Analysis Methods
Sensory neurons
Sensory Receptor Cells
Signal transduction
Social Sciences
Starvation
Temperature
Thermotaxis
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Summary:Animals detect changes in both their environment and their internal state and modify their behavior accordingly. Yet, it remains largely to be clarified how information of environment and internal state is integrated and how such integrated information modifies behavior. Well-fed C. elegans migrates to past cultivation temperature on a thermal gradient, which is disrupted when animals are starved. We recently reported that the neuronal activities synchronize between a thermosensory neuron AFD and an interneuron AIY, which is directly downstream of AFD, in well-fed animals, while this synchrony is disrupted in starved animals. However, it remained to be determined whether the disruption of the synchrony is derived from modulation of the transmitter release from AFD or from the modification of reception or signal transduction in AIY. By performing forward genetics on a transition of thermotaxis behavior along starvation, we revealed that OLA-1, an Obg-like ATPase, functions in AFD to promote disruption of AFD-AIY synchrony and behavioral transition. Our results suggest that the information of hunger is delivered to the AFD thermosensory neuron and gates transmitter release from AFD to disrupt thermotaxis, thereby shedding light onto a mechanism for the integration of environmental and internal state to modulate behavior.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1010219