Use of family history taking for hereditary neoplastic syndromes screening in primary health care: A systematic review protocol

Although most neoplasms result from complex interactions between the individual's genome and the environment, a percentage of cases is particularly due to inherited alterations that confer a greater predisposition to the development of tumors. Hereditary Neoplastic Syndromes have a high psychos...

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Bibliographic Details
Published in:PloS one 2022-07, Vol.17 (7), p.e0271286-e0271286
Main Authors: Pessanha, Raphael Manhães, Schuab, Sara Isabel Pimentel de Carvalho, Nunes, Karolini Zuqui, Lopes-Júnior, Luís Carlos
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Cancer
Cancer screening
Clinical trials
Decision making
Demographic aspects
Diagnosis
Disorders
Family medical history
Genetic counseling
Genetics
Genomes
Genomics
Health care
Health risks
Libraries
Malignancy
Medical screening
Medicine and Health Sciences
Meta-analysis
Neoplasia
Neoplasms
Primary care
Qualitative analysis
Research and Analysis Methods
Risk
Study Protocol
Synthesis
Systematic review
Technology
Tumors
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Summary:Although most neoplasms result from complex interactions between the individual's genome and the environment, a percentage of cases is particularly due to inherited alterations that confer a greater predisposition to the development of tumors. Hereditary Neoplastic Syndromes have a high psychosocial and economic burden, in addition to being characterized by an increased risk for one or more types of cancer, onset of malignancy at a young age, high risk of secondary malignancies, and occurrence in successive generations of the family. Personal and family history, as well as pedigree, may be useful resources to estimate the risk for developing cancer, especially in Primary Health Care settings. To identify and evaluate the evidence regarding the impact of using family history as a genomic technology for Hereditary Neoplastic Syndromes screening at Primary Health Care. This systematic review protocol was elaborated in compliance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols (PRISMA-P). We will include all observational as well as experimental study designs published up to end of July 2022, and studies covering the impact of family history on screening for Hereditary Neoplastic Syndromes in primary health care. Qualitative studies, as well as guidelines, reviews, and studies undertaken in hospitals, outpatient clinic, or medical environments will be excluded. Five databases will be searched, including MEDLINE/PubMed, Cochrane Library, EMBASE, Web of Science, and LILACS. Additional sources will also be retrieved, including Clinical trials.gov-NIH, The British Library, and Google Scholar. No restriction to language or date will be employed in the search strategy. Three investigators will select studies independently, perform data extraction, and conduct the critical appraisal of the risk of bias and overall quality of the selected studies according to their designs. Regarding data synthesis, the study characteristics will be summarized and presented in tables and results will be presented according to the study design. A qualitative synthesis of data will also be provided in this systematic review. To the best of our knowledge, this systematic review will be the first to identify and critically assess evidence regarding the impact of using family history as a genomic technology for Hereditary Neoplastic Syndromes screening in Primary Health Care settings worldwide. This study is expected to provide consistent evidence that
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0271286