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High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study
Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of...
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| Published in: | PLoS neglected tropical diseases 2022-07, Vol.16 (7), p.e0010570-e0010570 |
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| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| container_end_page | e0010570 |
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| container_title | PLoS neglected tropical diseases |
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| creator | Mulindwa, Julius Namulondo, Joyce Kitibwa, Anna Nassuuna, Jacent Nyangiri, Oscar Asanya Kimuda, Magambo Phillip Boobo, Alex Nerima, Barbara Busingye, Fred Candia, Rowel Namukuta, Annet Ssenyonga, Ronald Ukumu, Noah Ajal, Paul Adriko, Moses Noyes, Harry de Dood, Claudia J Corstjens, Paul L A M van Dam, Govert J Elliott, Alison M Matovu, Enock |
| description | Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease.
We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10-15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status.
The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83-87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI |
| doi_str_mv | 10.1371/journal.pntd.0010570 |
| format | article |
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We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10-15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status.
The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83-87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection.
High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area.</description><identifier>ISSN: 1935-2735</identifier><identifier>ISSN: 1935-2727</identifier><identifier>EISSN: 1935-2735</identifier><identifier>DOI: 10.1371/journal.pntd.0010570</identifier><identifier>PMID: 35895705</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>Adolescent ; Age ; Animals ; Antigens ; Antigens, Helminth - analysis ; Biology and Life Sciences ; Child ; Children ; Cognitive ability ; Cross-Sectional Studies ; Demographic aspects ; Diagnosis ; Disease control ; Distribution ; Earth Sciences ; Feces - chemistry ; Female ; Forecasts and trends ; Growth disorders ; Growth Disorders - epidemiology ; Humans ; Infections ; Male ; Medicine and Health Sciences ; Multivariate analysis ; Nutrition ; Nutritional status ; People and Places ; Praziquantel ; Prevalence ; Programmes ; Public health ; Sample size ; Sanitation ; Schistosoma mansoni ; Schistosomiasis ; Schistosomiasis mansoni - diagnosis ; Schistosomiasis mansoni - epidemiology ; Schools ; Sensitivity and Specificity ; Shorelines ; Social Sciences ; Stunting ; Surveying ; Tropical diseases ; Uganda - epidemiology ; Underweight ; Urine</subject><ispartof>PLoS neglected tropical diseases, 2022-07, Vol.16 (7), p.e0010570-e0010570</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Mulindwa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Mulindwa et al 2022 Mulindwa et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c624t-ae8116c885c4fcccd746952a1109e28f6090fc8f061594711b04c80da33849613</citedby><cites>FETCH-LOGICAL-c624t-ae8116c885c4fcccd746952a1109e28f6090fc8f061594711b04c80da33849613</cites><orcidid>0000-0003-0714-7032 ; 0000-0001-8634-5285 ; 0000-0003-2741-2921 ; 0000-0001-9748-1207 ; 0000-0001-9053-1988 ; 0000-0002-0656-200X ; 0000-0002-5419-2760 ; 0000-0002-6133-0674 ; 0000-0002-0004-0526 ; 0000-0003-3911-8359 ; 0000-0003-3773-0819</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2703170733/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2703170733?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35895705$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>WEBSTER, JOANNE P.</contributor><creatorcontrib>Mulindwa, Julius</creatorcontrib><creatorcontrib>Namulondo, Joyce</creatorcontrib><creatorcontrib>Kitibwa, Anna</creatorcontrib><creatorcontrib>Nassuuna, Jacent</creatorcontrib><creatorcontrib>Nyangiri, Oscar Asanya</creatorcontrib><creatorcontrib>Kimuda, Magambo Phillip</creatorcontrib><creatorcontrib>Boobo, Alex</creatorcontrib><creatorcontrib>Nerima, Barbara</creatorcontrib><creatorcontrib>Busingye, Fred</creatorcontrib><creatorcontrib>Candia, Rowel</creatorcontrib><creatorcontrib>Namukuta, Annet</creatorcontrib><creatorcontrib>Ssenyonga, Ronald</creatorcontrib><creatorcontrib>Ukumu, Noah</creatorcontrib><creatorcontrib>Ajal, Paul</creatorcontrib><creatorcontrib>Adriko, Moses</creatorcontrib><creatorcontrib>Noyes, Harry</creatorcontrib><creatorcontrib>de Dood, Claudia J</creatorcontrib><creatorcontrib>Corstjens, Paul L A M</creatorcontrib><creatorcontrib>van Dam, Govert J</creatorcontrib><creatorcontrib>Elliott, Alison M</creatorcontrib><creatorcontrib>Matovu, Enock</creatorcontrib><creatorcontrib>TrypanoGEN+ Research group</creatorcontrib><creatorcontrib>TrypanoGEN+ Research group</creatorcontrib><title>High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study</title><title>PLoS neglected tropical diseases</title><addtitle>PLoS Negl Trop Dis</addtitle><description>Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease.
We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10-15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status.
The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83-87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection.
High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area.</description><subject>Adolescent</subject><subject>Age</subject><subject>Animals</subject><subject>Antigens</subject><subject>Antigens, Helminth - analysis</subject><subject>Biology and Life Sciences</subject><subject>Child</subject><subject>Children</subject><subject>Cognitive ability</subject><subject>Cross-Sectional Studies</subject><subject>Demographic aspects</subject><subject>Diagnosis</subject><subject>Disease control</subject><subject>Distribution</subject><subject>Earth Sciences</subject><subject>Feces - chemistry</subject><subject>Female</subject><subject>Forecasts and trends</subject><subject>Growth disorders</subject><subject>Growth Disorders - epidemiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Medicine and Health Sciences</subject><subject>Multivariate analysis</subject><subject>Nutrition</subject><subject>Nutritional status</subject><subject>People and Places</subject><subject>Praziquantel</subject><subject>Prevalence</subject><subject>Programmes</subject><subject>Public health</subject><subject>Sample size</subject><subject>Sanitation</subject><subject>Schistosoma mansoni</subject><subject>Schistosomiasis</subject><subject>Schistosomiasis mansoni - diagnosis</subject><subject>Schistosomiasis mansoni - epidemiology</subject><subject>Schools</subject><subject>Sensitivity and Specificity</subject><subject>Shorelines</subject><subject>Social Sciences</subject><subject>Stunting</subject><subject>Surveying</subject><subject>Tropical diseases</subject><subject>Uganda - epidemiology</subject><subject>Underweight</subject><subject>Urine</subject><issn>1935-2735</issn><issn>1935-2727</issn><issn>1935-2735</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptktGK1DAUhoso7rr6BqIBQbxwxqRt2sYLYVjUXVjWC93rkDlN2gxpMpukC_tCPqfpTHeZkaXQhvT7_3OS82fZW4KXpKjJl40bvRVmubWxXWJMMK3xs-yUsIIu8rqgzw_WJ9mrEDYYU0Yb8jI7KWjDEk5Ps78XuuvR1ss7YaQFiZxCv6HXIbrgBoEGYYOzGmmrJETtLBK2RSGONmrbITG49A7QO2eQ6CRKUtN6aZMAgRuG0eqoZUDCTGDsJVqZtfRxca2N_IyunU973qKbLvmKr2iFwLsQUNhXE2aq1d6_zl4oYYJ8M3_Pspsf3_-cXyyufv28PF9dLaDKy7gQsiGkgqahUCoAaOuyYjQXhGAm80ZVmGEFjcIVoaysCVnjEhrciqJoSlaR4ix7v_fdGhf4fMWB5zUuSI3rokjE5Z5ondjwrdeD8PfcCc13G853XPiowUgOrMVAVFlKYGWl1LquGgygVEsVgfU6eX2bq43rQbYgbfTCHJke_7G6552742mujFKWDD7NBt7djjJEPugA0hhhpRtT39PpWY53fX_4D336dDPVpTjwNHSX6sJkylc1yasyL5o6UcsnqPS0ctDgrFRpuMeCjweCXgoT--DMOI04HIPlHtylwEv1eBkE8yn2D13zKfZ8jn2SvTu8yEfRQ86Lf1CmAbY</recordid><startdate>20220701</startdate><enddate>20220701</enddate><creator>Mulindwa, Julius</creator><creator>Namulondo, Joyce</creator><creator>Kitibwa, Anna</creator><creator>Nassuuna, Jacent</creator><creator>Nyangiri, Oscar Asanya</creator><creator>Kimuda, Magambo Phillip</creator><creator>Boobo, Alex</creator><creator>Nerima, Barbara</creator><creator>Busingye, Fred</creator><creator>Candia, Rowel</creator><creator>Namukuta, Annet</creator><creator>Ssenyonga, Ronald</creator><creator>Ukumu, Noah</creator><creator>Ajal, Paul</creator><creator>Adriko, Moses</creator><creator>Noyes, Harry</creator><creator>de Dood, Claudia J</creator><creator>Corstjens, Paul L A M</creator><creator>van Dam, Govert J</creator><creator>Elliott, Alison M</creator><creator>Matovu, Enock</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7SS</scope><scope>7T2</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>F1W</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>H95</scope><scope>H97</scope><scope>K9.</scope><scope>L.G</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-0714-7032</orcidid><orcidid>https://orcid.org/0000-0001-8634-5285</orcidid><orcidid>https://orcid.org/0000-0003-2741-2921</orcidid><orcidid>https://orcid.org/0000-0001-9748-1207</orcidid><orcidid>https://orcid.org/0000-0001-9053-1988</orcidid><orcidid>https://orcid.org/0000-0002-0656-200X</orcidid><orcidid>https://orcid.org/0000-0002-5419-2760</orcidid><orcidid>https://orcid.org/0000-0002-6133-0674</orcidid><orcidid>https://orcid.org/0000-0002-0004-0526</orcidid><orcidid>https://orcid.org/0000-0003-3911-8359</orcidid><orcidid>https://orcid.org/0000-0003-3773-0819</orcidid></search><sort><creationdate>20220701</creationdate><title>High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study</title><author>Mulindwa, Julius ; Namulondo, Joyce ; Kitibwa, Anna ; Nassuuna, Jacent ; Nyangiri, Oscar Asanya ; Kimuda, Magambo Phillip ; Boobo, Alex ; Nerima, Barbara ; Busingye, Fred ; Candia, Rowel ; Namukuta, Annet ; Ssenyonga, Ronald ; Ukumu, Noah ; Ajal, Paul ; Adriko, Moses ; Noyes, Harry ; de Dood, Claudia J ; Corstjens, Paul L A M ; van Dam, Govert J ; Elliott, Alison M ; Matovu, Enock</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c624t-ae8116c885c4fcccd746952a1109e28f6090fc8f061594711b04c80da33849613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Animals</topic><topic>Antigens</topic><topic>Antigens, Helminth - analysis</topic><topic>Biology and Life Sciences</topic><topic>Child</topic><topic>Children</topic><topic>Cognitive ability</topic><topic>Cross-Sectional Studies</topic><topic>Demographic aspects</topic><topic>Diagnosis</topic><topic>Disease control</topic><topic>Distribution</topic><topic>Earth Sciences</topic><topic>Feces - chemistry</topic><topic>Female</topic><topic>Forecasts and trends</topic><topic>Growth disorders</topic><topic>Growth Disorders - epidemiology</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Medicine and Health Sciences</topic><topic>Multivariate analysis</topic><topic>Nutrition</topic><topic>Nutritional status</topic><topic>People and Places</topic><topic>Praziquantel</topic><topic>Prevalence</topic><topic>Programmes</topic><topic>Public health</topic><topic>Sample size</topic><topic>Sanitation</topic><topic>Schistosoma mansoni</topic><topic>Schistosomiasis</topic><topic>Schistosomiasis mansoni - diagnosis</topic><topic>Schistosomiasis mansoni - epidemiology</topic><topic>Schools</topic><topic>Sensitivity and Specificity</topic><topic>Shorelines</topic><topic>Social Sciences</topic><topic>Stunting</topic><topic>Surveying</topic><topic>Tropical diseases</topic><topic>Uganda - epidemiology</topic><topic>Underweight</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mulindwa, Julius</creatorcontrib><creatorcontrib>Namulondo, Joyce</creatorcontrib><creatorcontrib>Kitibwa, Anna</creatorcontrib><creatorcontrib>Nassuuna, Jacent</creatorcontrib><creatorcontrib>Nyangiri, Oscar Asanya</creatorcontrib><creatorcontrib>Kimuda, Magambo Phillip</creatorcontrib><creatorcontrib>Boobo, Alex</creatorcontrib><creatorcontrib>Nerima, Barbara</creatorcontrib><creatorcontrib>Busingye, Fred</creatorcontrib><creatorcontrib>Candia, Rowel</creatorcontrib><creatorcontrib>Namukuta, Annet</creatorcontrib><creatorcontrib>Ssenyonga, Ronald</creatorcontrib><creatorcontrib>Ukumu, Noah</creatorcontrib><creatorcontrib>Ajal, Paul</creatorcontrib><creatorcontrib>Adriko, Moses</creatorcontrib><creatorcontrib>Noyes, Harry</creatorcontrib><creatorcontrib>de Dood, Claudia J</creatorcontrib><creatorcontrib>Corstjens, Paul L A M</creatorcontrib><creatorcontrib>van Dam, Govert J</creatorcontrib><creatorcontrib>Elliott, Alison M</creatorcontrib><creatorcontrib>Matovu, Enock</creatorcontrib><creatorcontrib>TrypanoGEN+ Research group</creatorcontrib><creatorcontrib>TrypanoGEN+ Research group</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 3: Aquatic Pollution & Environmental Quality</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mulindwa, Julius</au><au>Namulondo, Joyce</au><au>Kitibwa, Anna</au><au>Nassuuna, Jacent</au><au>Nyangiri, Oscar Asanya</au><au>Kimuda, Magambo Phillip</au><au>Boobo, Alex</au><au>Nerima, Barbara</au><au>Busingye, Fred</au><au>Candia, Rowel</au><au>Namukuta, Annet</au><au>Ssenyonga, Ronald</au><au>Ukumu, Noah</au><au>Ajal, Paul</au><au>Adriko, Moses</au><au>Noyes, Harry</au><au>de Dood, Claudia J</au><au>Corstjens, Paul L A M</au><au>van Dam, Govert J</au><au>Elliott, Alison M</au><au>Matovu, Enock</au><au>WEBSTER, JOANNE P.</au><aucorp>TrypanoGEN+ Research group</aucorp><aucorp>TrypanoGEN+ Research group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study</atitle><jtitle>PLoS neglected tropical diseases</jtitle><addtitle>PLoS Negl Trop Dis</addtitle><date>2022-07-01</date><risdate>2022</risdate><volume>16</volume><issue>7</issue><spage>e0010570</spage><epage>e0010570</epage><pages>e0010570-e0010570</pages><issn>1935-2735</issn><issn>1935-2727</issn><eissn>1935-2735</eissn><abstract>Knowing the prevalence of schistosomiasis is key to informing programmes to control and eliminate the disease as a public health problem. It is also important to understand the impact of infection on child growth and development in order to allocate appropriate resources and effort to the control of the disease.
We conducted a survey to estimate the prevalence of schistosomiasis among school aged children in villages along the Albert-Nile shore line in the district of Pakwach, North Western Uganda. A total of 914 children aged between 10-15 years were screened for Schistosoma mansoni using the POC-CCA and Kato Katz (KK) techniques. The infection intensities were assessed by POC-CCA and KK as well as CAA tests. The KK intensities were also correlated with POC-CCA and with CAA intensity. Anthropometric measurements were also taken and multivariate analysis was carried out to investigate their association with infection status.
The prevalence of schistosomiasis using the POC-CCA diagnostic test was estimated at 85% (95% CI: 83-87), being highest amongst children living closer to the Albert-Nile shoreline. Visual scoring of the POC-CCA results was more sensitive than the Kato Katz test and was positively correlated with the quantified infection intensities by the CAA test. The majority of the children were underweight (BMI<18.5), and most notably, boys had significantly lower height for age (stunting) than girls in the same age range (p < 0.0001), but this was not directly associated with S. mansoni infection.
High prevalence of S. mansoni infection in the region calls for more frequent mass drug administration with praziquantel. We observed high levels of stunting which was not associated with schistosomiasis. There is a need for improved nutrition among the children in the area.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>35895705</pmid><doi>10.1371/journal.pntd.0010570</doi><orcidid>https://orcid.org/0000-0003-0714-7032</orcidid><orcidid>https://orcid.org/0000-0001-8634-5285</orcidid><orcidid>https://orcid.org/0000-0003-2741-2921</orcidid><orcidid>https://orcid.org/0000-0001-9748-1207</orcidid><orcidid>https://orcid.org/0000-0001-9053-1988</orcidid><orcidid>https://orcid.org/0000-0002-0656-200X</orcidid><orcidid>https://orcid.org/0000-0002-5419-2760</orcidid><orcidid>https://orcid.org/0000-0002-6133-0674</orcidid><orcidid>https://orcid.org/0000-0002-0004-0526</orcidid><orcidid>https://orcid.org/0000-0003-3911-8359</orcidid><orcidid>https://orcid.org/0000-0003-3773-0819</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1935-2735 |
| ispartof | PLoS neglected tropical diseases, 2022-07, Vol.16 (7), p.e0010570-e0010570 |
| issn | 1935-2735 1935-2727 1935-2735 |
| language | eng |
| recordid | cdi_plos_journals_2703170733 |
| source | Open Access: PubMed Central; Publicly Available Content Database |
| subjects | Adolescent Age Animals Antigens Antigens, Helminth - analysis Biology and Life Sciences Child Children Cognitive ability Cross-Sectional Studies Demographic aspects Diagnosis Disease control Distribution Earth Sciences Feces - chemistry Female Forecasts and trends Growth disorders Growth Disorders - epidemiology Humans Infections Male Medicine and Health Sciences Multivariate analysis Nutrition Nutritional status People and Places Praziquantel Prevalence Programmes Public health Sample size Sanitation Schistosoma mansoni Schistosomiasis Schistosomiasis mansoni - diagnosis Schistosomiasis mansoni - epidemiology Schools Sensitivity and Specificity Shorelines Social Sciences Stunting Surveying Tropical diseases Uganda - epidemiology Underweight Urine |
| title | High prevalence of Schistosoma mansoni infection and stunting among school age children in communities along the Albert-Nile, Northern Uganda: A cross sectional study |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T23%3A15%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=High%20prevalence%20of%20Schistosoma%20mansoni%20infection%20and%20stunting%20among%20school%20age%20children%20in%20communities%20along%20the%20Albert-Nile,%20Northern%20Uganda:%20A%20cross%20sectional%20study&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Mulindwa,%20Julius&rft.aucorp=TrypanoGEN+%20Research%20group&rft.date=2022-07-01&rft.volume=16&rft.issue=7&rft.spage=e0010570&rft.epage=e0010570&rft.pages=e0010570-e0010570&rft.issn=1935-2735&rft.eissn=1935-2735&rft_id=info:doi/10.1371/journal.pntd.0010570&rft_dat=%3Cgale_plos_%3EA712642387%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c624t-ae8116c885c4fcccd746952a1109e28f6090fc8f061594711b04c80da33849613%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2703170733&rft_id=info:pmid/35895705&rft_galeid=A712642387&rfr_iscdi=true |