Neurons contribute to pathology in a mouse model of Krabbe disease in a cell-autonomous manner

In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous...

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Bibliographic Details
Published in:PLoS biology 2022-07, Vol.20 (7), p.e3001706-e3001706
Main Authors: Brites, Pedro, Sousa, Monica M
Format: Article
Language:English
Subjects:
Analysis
Biology
Biology and Life Sciences
Care and treatment
Enzymes
Fibroblasts
Globoid cell leukodystrophy
Medicine and Health Sciences
Mutation
Nervous system
Neurodegeneration
Neuronal-glial interactions
Neurons
Pathogenesis
Pathology
Primer
Research and Analysis Methods
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Summary:In this issue of PLOS Biology, Kreher and colleagues show in a mouse model that in vivo, neurons and not only myelinating glia are primary effectors of disease progression in Krabbe disease. The neuron-specific model generated allows the unprecedented capacity to investigate the neuronal autonomous component of this disorder.
ISSN:1545-7885
1544-9173
1545-7885
DOI:10.1371/journal.pbio.3001706