Spatiotemporal cluster patterns of hand, foot, and mouth disease at the province level in mainland China, 2011–2018

Although three monovalent EV-A71 vaccines have been launched in mainland China since 2016, hand, foot, and mouth disease (HFMD) still causes a considerable disease burden in China. Vaccines’ use may change the epidemiological characters of HFMD. Spatial autocorrelation analysis and space-time scan s...

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Bibliographic Details
Published in:PloS one 2022-08, Vol.17 (8), p.e0270061-e0270061
Main Authors: Wu, Yuanzhe, Wang, Tingwei, Zhao, Mingyi, Dong, Shumin, Wang, Shiwen, Shi, Jingcheng
Format: Article
Language:English
Subjects:
Analysis
Biological markers
Biology and Life Sciences
Clustering
Computer and Information Sciences
Coxsackievirus infections
Diagnosis
Disease control
Disease prevention
Distribution
Distribution patterns
Earth Sciences
Economic analysis
Economic factors
Epidemiology
Hand-foot-and-mouth disease
Heterogeneity
Hospitals
Humidity
Immunization
Impact analysis
Infectious diseases
Medicine and Health Sciences
Meteorological effects
Mortality
People and Places
Per capita
Population density
Provinces
Public health
Social factors
Socioeconomic factors
Socioeconomics
Spacetime
Spatial analysis
Spatial distribution
Spatial heterogeneity
Statistical analysis
Temporal distribution
Time series
Vaccines
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Summary:Although three monovalent EV-A71 vaccines have been launched in mainland China since 2016, hand, foot, and mouth disease (HFMD) still causes a considerable disease burden in China. Vaccines’ use may change the epidemiological characters of HFMD. Spatial autocorrelation analysis and space-time scan statistics analysis were used to explore the spatiotemporal distribution pattern of this disease at the provincial level in mainland China. The effects of meteorological factors, socio-economic factors, and health resources on HFMD incidence were analyzed using Geodetector. Interrupted time series (ITS) was used to analyze the impact of the EV-A71 vaccine on the incidence of HFMD. This study found that the median annual incidence of HFMD was 153.78 per 100,000 (ranging from 120.79 to 205.06) in mainland China from 2011 to 2018. Two peaks of infections were observed per year. Children 5 years and under were the main morbid population. The spatial distribution of HFMD was presented a significant clustering pattern in each year (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0270061