Association between serum chloride levels with mortality in critically ill patients with acute kidney injury: An observational multicenter study employing the eICU database

The effect of the serum chloride (Cl) level on mortality in critically ill patients with acute kidney injury (AKI) remains unknown. We sought an association between mortality and serum Cl. We identified AKI patients in the eICU Collaborative Research Database from 2014 to 2015 at 208 US hospitals. T...

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Bibliographic Details
Published in:PloS one 2022-08, Vol.17 (8), p.e0273283-e0273283
Main Authors: Zhu, Xu, Xue, Jing, Liu, Zheng, Dai, Wenjie, Xiang, Jingsha, Xu, Hui, Zhou, Qiaoling, Zhou, Quan, Chen, Wenhang
Format: Article
Language:English
Subjects:
Acute renal failure
Age
Biology and Life Sciences
Cardiovascular disease
Chlorides
Confidence intervals
Coronary vessels
Creatinine
Critically ill
Development and progression
Diabetes
Dichloropropane
Diuretics
Ethnicity
Health aspects
Health risks
Heart failure
Hyperchloremia
Hypertension
Intensive care
Kidney diseases
Kidneys
Laboratories
Medicine and Health Sciences
Mortality
Patient outcomes
Patients
Physical Sciences
Physiological aspects
Physiology
Pneumonia
Regression analysis
Regression models
Review boards
Sepsis
Serum
Statistical analysis
Structured Query Language-SQL
Survival
Vein & artery diseases
Ventilators
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Summary:The effect of the serum chloride (Cl) level on mortality in critically ill patients with acute kidney injury (AKI) remains unknown. We sought an association between mortality and serum Cl. We identified AKI patients in the eICU Collaborative Research Database from 2014 to 2015 at 208 US hospitals. The outcomes included in-hospital and intensive care unit (ICU) mortality. Time-varying covariates Cox regression models and the Kaplan-Meier (K-M) curves were used to assess the association between serum Cl levels and mortality. Multivariable adjusted restricted cubic spline models were used to analyze the potential nonlinear relationship between mortality and serum Cl. In total, 4,234 AKI patients were included in the study. Compared with normochloremia (98[less than or equal to]chloride
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0273283