Hypoalbuminemia for the prediction of survival in patients with stage IVB cervical cancer

We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlat...

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Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0273876-e0273876
Main Authors: Yoshikawa, Nobuhisa, Yoshihara, Masato, Tamauchi, Satoshi, Ikeda, Yoshiki, Yokoi, Akira, Kajiyama, Hiroaki
Format: Article
Language:English
Subjects:
Albumin
Biology and Life Sciences
Blood
Cancer
Cancer therapies
Cervical cancer
Cervix
Chemotherapy
Development and progression
Health aspects
Hospitals
Laboratories
Malnutrition
Medical diagnosis
Medical prognosis
Medical records
Medicine and Health Sciences
Metastases
Metastasis
Multivariate analysis
Palliative care
Patient outcomes
Patients
Prognosis
Radiation therapy
Review boards
Serum albumin
Survival
Survival analysis
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Summary:We evaluated the prognostic significance of malnutrition in patients with metastatic cervical cancer. In this study, we retrospectively analyzed the cases of 43 patients with stage IVB (FIGO2018) cervical cancer treated at our institute from December 2004 to December 2017. We determined the correlation between clinicopathological characteristics and survival by performing univariate and multivariate analyses. The serum albumin value at diagnosis was used as an index of malnutrition. The median follow-up period was 16.4 months (range, 0.9–91.4 months). On Kaplan-Meier analysis, the 1- and 2-year overall survival (OS) rates for all patients were 61.6% and 48.6%, respectively. The optimal serum albumin for predicting 1-year survival was 3.3 g/dL, as determined by the receiver operating characteristic curve to maximize the area under the curve. The OS of the patients with albumin >3.3 g/dL (n = 28) was significantly better than that of the patients with albumin ≤3.3 g/dL (n = 15) (p = 0.004). The univariate and multivariate analyses revealed that pretreatment serum albumin and mode of primary treatment were significantly associated with survival in patients with stage IVB cervical cancer. Hypoalbuminemia was an unfavorable prognostic factor for patients with metastatic cervical cancer.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0273876