Anemia in female patients with myasthenia gravis

Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder, and is more common in women than in men. Anemia is also more common in women. The purpose of this study was to investigate factors associated with anemia and the negative impact of anemia in female MG patients. We investiga...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0273720-e0273720
Main Authors: Sekiguchi, Koji, Ishizuchi, Kei, Takizawa, Tsubasa, Motegi, Haruhiko, Oyama, Munenori, Nakahara, Jin, Suzuki, Shigeaki
Format: Article
Language:English
Subjects:
Activities of daily living
Anemia
Autoantibodies
Autoimmune diseases
Biology and Life Sciences
Blood diseases
Body mass
Body mass index
Body size
Calcineurin
Calcineurin inhibitors
Complications and side effects
COVID-19
Diagnosis
Evaluation
Females
Gynecology
Health aspects
Hemoglobin
Immunosuppressive agents
Immunotherapy
Iron
Medicine and Health Sciences
Myasthenia
Myasthenia gravis
Neuromuscular junctions
Patients
Prednisolone
Quality of life
Women
Womens health
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Myasthenia gravis (MG) is the most common autoimmune neuromuscular disorder, and is more common in women than in men. Anemia is also more common in women. The purpose of this study was to investigate factors associated with anemia and the negative impact of anemia in female MG patients. We investigated factors related to MG and anemia in 215 female patients with MG, who were attending the MG clinic of Keio Hospital between January and December 2021. We statistically evaluated clinical factors related to anemia in patients with and without anemia. Eighty-five patients (40%) had anemia in the past, and 130 patients did not have anemia in the past. There were no significant differences in age at study, age at MG onset, body mass index, or frequency of autoantibodies between the anemia and non-anemia groups. MG severity evaluated by the MG Foundation of America classification was greater in the anemia group than in the non-anemia group. History of anemia was associated with immunosuppressive treatment, such as prednisolone and calcineurin inhibitor treatment. There was a correlation between hemoglobin levels and the MG-quality of life score. Long term immunosuppressive therapy can cause anemia in female MG patients. Anemia may negatively affect the quality of life of female MG patients.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0273720