The differential impacts of early detection and accelerated antiretroviral therapy on the epidemiologic trend of sexually acquired HIV infection in Hong Kong

To assess impacts of early detection and prompt antiretroviral therapy (ART) on the latest epidemiologic situation to inform intervention strategy. We analysed data from two clinical cohorts in Hong Kong where sexual transmission accounted for the majority of HIV infections. The two cohorts comprise...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0274498-e0274498
Main Authors: Poon, Paul Kwok-ming, Wong, Ngai-sze, Leung, Wai-shing, Wong, Bonnie Chun-kwan, Kwong, Tsz-shan, Kwan, Tsz-ho, Lui, Grace Chung-yan, Tsang, Owen Tak-yin, Lee, Man-po, Wong, Ka-hing, Lee, Shui-shan
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
AIDS
Antiretroviral agents
Antiretroviral drugs
Antiretroviral therapy
Biology and Life Sciences
Care and treatment
CD4 antigen
Complications and side effects
Consent
Diagnosis
Disease transmission
Drug therapy
Epidemics
Epidemiology
Ethnicity
Gays & lesbians
Highly active antiretroviral therapy
HIV
HIV (Viruses)
Human immunodeficiency virus
Infections
Laboratories
Medical diagnosis
Medical tests
Medicine and health sciences
Mens health
Patient outcomes
Patients
People and Places
Public health
Sexually transmitted diseases
STD
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To assess impacts of early detection and prompt antiretroviral therapy (ART) on the latest epidemiologic situation to inform intervention strategy. We analysed data from two clinical cohorts in Hong Kong where sexual transmission accounted for the majority of HIV infections. The two cohorts comprised patients newly diagnosed in 2007-2008 and 2016-2018 respectively. Secular trend and differences between men who have sex with men (MSM) and heterosexual patients were examined. Predictors of late presentation (defined as CD4 [less than or equal to]350 or AIDS-defining illness within 3 months of diagnosis) and prolonged interval between diagnosis and ART initiation were assessed by multivariable regressions. There were 1,136 newly diagnosed HIV patients with 644 in the first and 492 in the second cohort, a majority (91.7%) presented with sexually acquired infection. There were less MSM in the first than the second cohort (50.3%% vs 87.8%, X.sup.2 = 117.05, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0274498