Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life

Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and m...

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Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0268497-e0268497
Main Authors: Liani, Rossella, La Torre, Sara, Liani, Valentina, Melchiorre, Angela, D'Ettorre, Danilo, Tripaldi, Romina, Lattanzio, Stefano, Di Luzio, Rossano, Coli, Mauro, Velussi, Carlo
Format: Article
Language:English
Subjects:
Analysis
Biology and Life Sciences
Blood circulation
Blood pressure
Care and treatment
Chronic illnesses
Chronic kidney failure
Creatinine
Diabetes
Diabetes mellitus
Diagnosis
Disease control
Electric fields
Electrostatic properties
Enzyme immunoassay
Heart rate
Hemodialysis
Hemoglobin
Immunoassay
Inflammation
Kidney diseases
Kidneys
Laboratories
Medical prognosis
Medicine and Health Sciences
Metabolism
Motility
Neurotransmitters
Nitric oxide
Nutrition
Patients
Perceptions
Perfusion
Quality of life
Questionnaires
Skin
Structure-function relationships
Tissues
Type 2 diabetes
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Summary:Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0268497