Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life

Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and m...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0268497-e0268497
Main Authors: Liani, Rossella, La Torre, Sara, Liani, Valentina, Melchiorre, Angela, D'Ettorre, Danilo, Tripaldi, Romina, Lattanzio, Stefano, Di Luzio, Rossano, Coli, Mauro, Velussi, Carlo
Format: Article
Language:English
Subjects:
Analysis
Biology and Life Sciences
Blood circulation
Blood pressure
Care and treatment
Chronic illnesses
Chronic kidney failure
Creatinine
Diabetes
Diabetes mellitus
Diagnosis
Disease control
Electric fields
Electrostatic properties
Enzyme immunoassay
Heart rate
Hemodialysis
Hemoglobin
Immunoassay
Inflammation
Kidney diseases
Kidneys
Laboratories
Medical prognosis
Medicine and Health Sciences
Metabolism
Motility
Neurotransmitters
Nitric oxide
Nutrition
Patients
Perceptions
Perfusion
Quality of life
Questionnaires
Skin
Structure-function relationships
Tissues
Type 2 diabetes
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites cdi_FETCH-LOGICAL-c519t-11d02c995a5f4135078144ea80d84a99d224daef4bbc0f9c75780ee69658eb4b3
container_end_page e0268497
container_issue 9
container_start_page e0268497
container_title PloS one
container_volume 17
creator Liani, Rossella
La Torre, Sara
Liani, Valentina
Melchiorre, Angela
D'Ettorre, Danilo
Tripaldi, Romina
Lattanzio, Stefano
Di Luzio, Rossano
Coli, Mauro
Velussi, Carlo
description Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.
doi_str_mv 10.1371/journal.pone.0268497
format article
fullrecord <record><control><sourceid>gale_plos_</sourceid><recordid>TN_cdi_plos_journals_2714859773</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A717809754</galeid><doaj_id>oai_doaj_org_article_1cb230ede58e498cb914de9e36de055c</doaj_id><sourcerecordid>A717809754</sourcerecordid><originalsourceid>FETCH-LOGICAL-c519t-11d02c995a5f4135078144ea80d84a99d224daef4bbc0f9c75780ee69658eb4b3</originalsourceid><addsrcrecordid>eNptUl1rFDEUHUSxtfoPBAO-VHDXZPIxEx-EUlotVBSqzyGT3OymzE6mSaawv8E_bbY7iislDwnJOefec3Kr6jXBS0Ib8uE2THHQ_XIMAyxxLVommyfVMZG0Xoga06f_nI-qFyndYsxpK8Tz6ogKgptWtMfVr5s82S0KDo1Tn8Ai6MHkGFLW2RvkPPQWnX6_uLl8h_yA8hrQCNFNyYfhgQXRj2uIukfZpzRB-oi-ehODHlY-jDqvt-_RMOXo846hB4vuJt37vJ3ZBvw9RNR7By-rZ06XJl7N-0n18_Lix_mXxfW3z1fnZ9cLw4nMC0Isro2UXHPHCOXFCWEMdItty7SUtq6Z1eBY1xnspGl402IAIQVvoWMdPane7HXHPiQ155hU3RDWctk0tCCu9ggb9K0ao9_ouFVBe_VwEeJK6Vjy6UER09UUg4UizmRrOkmYBQlUWMCcm6L1aa42dRuwBoZc0joQPXwZ_Fqtwr2SrLTCcRE4nQViuCsBZ7XxyUDf6wHCtO9bcCbwDvr2P-jj7mbUShcDfnCh1DU7UXXWkBKWbDgrqOUjqLIsbLwpQ-d8uT8gsD2h_H5KEdxfjwSr3cj-aUbtRlbNI0t_A-764UU</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2714859773</pqid></control><display><type>article</type><title>Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life</title><source>PubMed Central（OA）</source><source>ProQuest Publicly Available Content database</source><creator>Liani, Rossella ; La Torre, Sara ; Liani, Valentina ; Melchiorre, Angela ; D'Ettorre, Danilo ; Tripaldi, Romina ; Lattanzio, Stefano ; Di Luzio, Rossano ; Coli, Mauro ; Velussi, Carlo</creator><contributor>Singh, Kanhaiya</contributor><creatorcontrib>Liani, Rossella ; La Torre, Sara ; Liani, Valentina ; Melchiorre, Angela ; D'Ettorre, Danilo ; Tripaldi, Romina ; Lattanzio, Stefano ; Di Luzio, Rossano ; Coli, Mauro ; Velussi, Carlo ; Singh, Kanhaiya</creatorcontrib><description>Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0268497</identifier><identifier>PMID: 36107868</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Analysis ; Biology and Life Sciences ; Blood circulation ; Blood pressure ; Care and treatment ; Chronic illnesses ; Chronic kidney failure ; Creatinine ; Diabetes ; Diabetes mellitus ; Diagnosis ; Disease control ; Electric fields ; Electrostatic properties ; Enzyme immunoassay ; Heart rate ; Hemodialysis ; Hemoglobin ; Immunoassay ; Inflammation ; Kidney diseases ; Kidneys ; Laboratories ; Medical prognosis ; Medicine and Health Sciences ; Metabolism ; Motility ; Neurotransmitters ; Nitric oxide ; Nutrition ; Patients ; Perceptions ; Perfusion ; Quality of life ; Questionnaires ; Skin ; Structure-function relationships ; Tissues ; Type 2 diabetes</subject><ispartof>PloS one, 2022-09, Vol.17 (9), p.e0268497-e0268497</ispartof><rights>COPYRIGHT 2022 Public Library of Science</rights><rights>2022 Liani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 Liani et al 2022 Liani et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c519t-11d02c995a5f4135078144ea80d84a99d224daef4bbc0f9c75780ee69658eb4b3</cites><orcidid>0000-0002-1523-530X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2714859773/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2714859773?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids></links><search><contributor>Singh, Kanhaiya</contributor><creatorcontrib>Liani, Rossella</creatorcontrib><creatorcontrib>La Torre, Sara</creatorcontrib><creatorcontrib>Liani, Valentina</creatorcontrib><creatorcontrib>Melchiorre, Angela</creatorcontrib><creatorcontrib>D'Ettorre, Danilo</creatorcontrib><creatorcontrib>Tripaldi, Romina</creatorcontrib><creatorcontrib>Lattanzio, Stefano</creatorcontrib><creatorcontrib>Di Luzio, Rossano</creatorcontrib><creatorcontrib>Coli, Mauro</creatorcontrib><creatorcontrib>Velussi, Carlo</creatorcontrib><title>Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life</title><title>PloS one</title><description>Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.</description><subject>Analysis</subject><subject>Biology and Life Sciences</subject><subject>Blood circulation</subject><subject>Blood pressure</subject><subject>Care and treatment</subject><subject>Chronic illnesses</subject><subject>Chronic kidney failure</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diagnosis</subject><subject>Disease control</subject><subject>Electric fields</subject><subject>Electrostatic properties</subject><subject>Enzyme immunoassay</subject><subject>Heart rate</subject><subject>Hemodialysis</subject><subject>Hemoglobin</subject><subject>Immunoassay</subject><subject>Inflammation</subject><subject>Kidney diseases</subject><subject>Kidneys</subject><subject>Laboratories</subject><subject>Medical prognosis</subject><subject>Medicine and Health Sciences</subject><subject>Metabolism</subject><subject>Motility</subject><subject>Neurotransmitters</subject><subject>Nitric oxide</subject><subject>Nutrition</subject><subject>Patients</subject><subject>Perceptions</subject><subject>Perfusion</subject><subject>Quality of life</subject><subject>Questionnaires</subject><subject>Skin</subject><subject>Structure-function relationships</subject><subject>Tissues</subject><subject>Type 2 diabetes</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUl1rFDEUHUSxtfoPBAO-VHDXZPIxEx-EUlotVBSqzyGT3OymzE6mSaawv8E_bbY7iislDwnJOefec3Kr6jXBS0Ib8uE2THHQ_XIMAyxxLVommyfVMZG0Xoga06f_nI-qFyndYsxpK8Tz6ogKgptWtMfVr5s82S0KDo1Tn8Ai6MHkGFLW2RvkPPQWnX6_uLl8h_yA8hrQCNFNyYfhgQXRj2uIukfZpzRB-oi-ehODHlY-jDqvt-_RMOXo846hB4vuJt37vJ3ZBvw9RNR7By-rZ06XJl7N-0n18_Lix_mXxfW3z1fnZ9cLw4nMC0Isro2UXHPHCOXFCWEMdItty7SUtq6Z1eBY1xnspGl402IAIQVvoWMdPane7HXHPiQ155hU3RDWctk0tCCu9ggb9K0ao9_ouFVBe_VwEeJK6Vjy6UER09UUg4UizmRrOkmYBQlUWMCcm6L1aa42dRuwBoZc0joQPXwZ_Fqtwr2SrLTCcRE4nQViuCsBZ7XxyUDf6wHCtO9bcCbwDvr2P-jj7mbUShcDfnCh1DU7UXXWkBKWbDgrqOUjqLIsbLwpQ-d8uT8gsD2h_H5KEdxfjwSr3cj-aUbtRlbNI0t_A-764UU</recordid><startdate>20220915</startdate><enddate>20220915</enddate><creator>Liani, Rossella</creator><creator>La Torre, Sara</creator><creator>Liani, Valentina</creator><creator>Melchiorre, Angela</creator><creator>D'Ettorre, Danilo</creator><creator>Tripaldi, Romina</creator><creator>Lattanzio, Stefano</creator><creator>Di Luzio, Rossano</creator><creator>Coli, Mauro</creator><creator>Velussi, Carlo</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0002-1523-530X</orcidid></search><sort><creationdate>20220915</creationdate><title>Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life</title><author>Liani, Rossella ; La Torre, Sara ; Liani, Valentina ; Melchiorre, Angela ; D'Ettorre, Danilo ; Tripaldi, Romina ; Lattanzio, Stefano ; Di Luzio, Rossano ; Coli, Mauro ; Velussi, Carlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-11d02c995a5f4135078144ea80d84a99d224daef4bbc0f9c75780ee69658eb4b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Analysis</topic><topic>Biology and Life Sciences</topic><topic>Blood circulation</topic><topic>Blood pressure</topic><topic>Care and treatment</topic><topic>Chronic illnesses</topic><topic>Chronic kidney failure</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diagnosis</topic><topic>Disease control</topic><topic>Electric fields</topic><topic>Electrostatic properties</topic><topic>Enzyme immunoassay</topic><topic>Heart rate</topic><topic>Hemodialysis</topic><topic>Hemoglobin</topic><topic>Immunoassay</topic><topic>Inflammation</topic><topic>Kidney diseases</topic><topic>Kidneys</topic><topic>Laboratories</topic><topic>Medical prognosis</topic><topic>Medicine and Health Sciences</topic><topic>Metabolism</topic><topic>Motility</topic><topic>Neurotransmitters</topic><topic>Nitric oxide</topic><topic>Nutrition</topic><topic>Patients</topic><topic>Perceptions</topic><topic>Perfusion</topic><topic>Quality of life</topic><topic>Questionnaires</topic><topic>Skin</topic><topic>Structure-function relationships</topic><topic>Tissues</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liani, Rossella</creatorcontrib><creatorcontrib>La Torre, Sara</creatorcontrib><creatorcontrib>Liani, Valentina</creatorcontrib><creatorcontrib>Melchiorre, Angela</creatorcontrib><creatorcontrib>D'Ettorre, Danilo</creatorcontrib><creatorcontrib>Tripaldi, Romina</creatorcontrib><creatorcontrib>Lattanzio, Stefano</creatorcontrib><creatorcontrib>Di Luzio, Rossano</creatorcontrib><creatorcontrib>Coli, Mauro</creatorcontrib><creatorcontrib>Velussi, Carlo</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Proquest Nursing &amp; Allied Health Source</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Meteorological &amp; Geoastrophysical Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Agricultural Science Collection</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Materials Science &amp; Engineering Collection</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>Agricultural &amp; Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Materials Science Database</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>Meteorological &amp; Geoastrophysical Abstracts - Academic</collection><collection>ProQuest Engineering Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Agriculture Science Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>Engineering Database</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>ProQuest advanced technologies &amp; aerospace journals</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Environmental Science Database</collection><collection>Materials science collection</collection><collection>ProQuest Publicly Available Content database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Engineering collection</collection><collection>Environmental Science Collection</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liani, Rossella</au><au>La Torre, Sara</au><au>Liani, Valentina</au><au>Melchiorre, Angela</au><au>D'Ettorre, Danilo</au><au>Tripaldi, Romina</au><au>Lattanzio, Stefano</au><au>Di Luzio, Rossano</au><au>Coli, Mauro</au><au>Velussi, Carlo</au><au>Singh, Kanhaiya</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life</atitle><jtitle>PloS one</jtitle><date>2022-09-15</date><risdate>2022</risdate><volume>17</volume><issue>9</issue><spage>e0268497</spage><epage>e0268497</epage><pages>e0268497-e0268497</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><abstract>Microangiopathy compromises the structural and functional integrity of organs and tissues in patients with type II diabetes mellitus (T2DM) negatively affecting the perceived quality of life. Nitric oxide (NO) is a multifunctional signalling molecule, acting as a vasodilator, neurotransmitter, and modulator of inflammatory processes. Patients with type II diabetes mellitus and chronic kidney disease, controlled from glycaemic status, were treated or not with pulsed electrostatic field (PESF) cycles to evaluate effect on the perfusion of peripheral tissues. Everyone was monitored for the metabolic profile, and we tested circulating NO with a commercial enzyme immunoassay kit. In addition, we tested the perceived quality of life of patients before/after a PESF cycle using a questionnaire. Patients treated with PESF were improved circulating NO levels, significant changes in systolic and diastolic blood pressure, heart rate and were more homogeneous for their metabolic profile. The questionnaire showed also a marked improvement in the perceived quality of life. The use of pulsed electrostatic fields has allowed us to observe an improvement in the metabolic, psychological, and clinical profile in patients with T2DM and chronic kidney disease whose pathological profile is strongly compromised.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>36107868</pmid><doi>10.1371/journal.pone.0268497</doi><orcidid>https://orcid.org/0000-0002-1523-530X</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1932-6203
ispartof PloS one, 2022-09, Vol.17 (9), p.e0268497-e0268497
issn 1932-6203
1932-6203
language eng
recordid cdi_plos_journals_2714859773
source PubMed Central（OA）; ProQuest Publicly Available Content database
subjects Analysis
Biology and Life Sciences
Blood circulation
Blood pressure
Care and treatment
Chronic illnesses
Chronic kidney failure
Creatinine
Diabetes
Diabetes mellitus
Diagnosis
Disease control
Electric fields
Electrostatic properties
Enzyme immunoassay
Heart rate
Hemodialysis
Hemoglobin
Immunoassay
Inflammation
Kidney diseases
Kidneys
Laboratories
Medical prognosis
Medicine and Health Sciences
Metabolism
Motility
Neurotransmitters
Nitric oxide
Nutrition
Patients
Perceptions
Perfusion
Quality of life
Questionnaires
Skin
Structure-function relationships
Tissues
Type 2 diabetes
title Study of pulsed electrostatic field (PESF) in the perfusion of peripheral tissues: Microangiopathy, nutrition and quality of perceiver life
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-19T08%3A03%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%20of%20pulsed%20electrostatic%20field%20(PESF)%20in%20the%20perfusion%20of%20peripheral%20tissues:%20Microangiopathy,%20nutrition%20and%20quality%20of%20perceiver%20life&rft.jtitle=PloS%20one&rft.au=Liani,%20Rossella&rft.date=2022-09-15&rft.volume=17&rft.issue=9&rft.spage=e0268497&rft.epage=e0268497&rft.pages=e0268497-e0268497&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0268497&rft_dat=%3Cgale_plos_%3EA717809754%3C/gale_plos_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c519t-11d02c995a5f4135078144ea80d84a99d224daef4bbc0f9c75780ee69658eb4b3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2714859773&rft_id=info:pmid/36107868&rft_galeid=A717809754&rfr_iscdi=true