Predictors for development of oxaliplatin-induced peripheral neuropathy in cancer patients as determined by ordered logistic regression analysis

Oxaliplatin causes acute cold-induced neurotoxicity and chronic cumulative neuropathy, which can require dose modification and impacts quality of life. However, effective strategies for managing oxaliplatin-induced peripheral neuropathy (OIPN) among affected patients remain elusive. This retrospecti...

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Bibliographic Details
Published in:PloS one 2022-09, Vol.17 (9), p.e0275481-e0275481
Main Authors: Kanbayashi, Yuko, Ishikawa, Takeshi, Kuriu, Yoshiaki, Otsuji, Eigo, Takayama, Koichi
Format: Article
Language:English
Subjects:
Biology and Life Sciences
Body fat
Body mass
Body mass index
Body size
Cancer
Care and treatment
Chemotherapy
Colorectal cancer
Confidence intervals
Creatinine
Dosage
Drug dosages
Evaluation
Females
Gastric cancer
Medical ethics
Medicine and Health Sciences
Multivariate analysis
Neurotoxicity
Oxaliplatin
Pain
Patient outcomes
Patients
Peripheral neuropathy
Physical Sciences
Quality of life
Questionnaires
Regression analysis
Research and Analysis Methods
Risk analysis
Risk factors
Sex
Statistical analysis
Stomach cancer
Terminology
Values
Variables
Women
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Summary:Oxaliplatin causes acute cold-induced neurotoxicity and chronic cumulative neuropathy, which can require dose modification and impacts quality of life. However, effective strategies for managing oxaliplatin-induced peripheral neuropathy (OIPN) among affected patients remain elusive. This retrospective study aimed to identify predictors for the development of OIPN. Significant risk factors identified included higher body mass index (BMI) (odds ratio [OR] = 1.06, 95% confidence interval [CI] = 1.00-1.12; P = 0.043), female sex (OR = 1.67, 95%CI = 1.06-2.61; P = 0.026) and higher total dosage (OR = 2.39, 95%CI = 1.67-3.42; P = < 0.0001). High BMI, female sex and high total dosage were identified as significant predictors for the development of OIPN.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0275481