Formal Comment on "Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques" by Bochart et al. (2021)

• Published in: PLoS pathogens 2022-09, Vol.18 (9), p.e1010831-e1010831
• Main Authors: Bohm, Rudolf P, Breed, Matthew W, Cohen, Joyce K, Haertel, Andrew J, Halliday, Lisa C, Kramer, Joshua A, Lieberman, Mia T, Rice, Kelly A, Roberts, Jeffery A, Russell-Logrigue, Kasi E, Salyards, Gregory W, Scorpio, Diana G, Weese, J Scott
• Format: Article
• Language: English
• Subjects: Animals; Anti-infective agents; Antiinfectives and antibacterials; Antimicrobial agents; Bacteria; Biology and Life Sciences; Campylobacter; Combined Modality Therapy; Complications and side effects; Dosage and administration; Drug resistance; Drug resistance in microorganisms; Drug therapy; Formal Comment; Gastrointestinal diseases; Health care; Inflammation; Macaca mulatta; Medicine and Health Sciences; Mitigation; Pandemics; Pathogens; Public health; Reproducibility; Risk factors; Shigella; Simian Acquired Immunodeficiency Syndrome; Simian Immunodeficiency Virus; Staphylococcus infections
• ISSN: 1553-7374; 1553-7366; 1553-7374
• DOI: 10.1371/journal.ppat.1010831

[...]of these resistance patterns, the World Health Organization recently highlighted the need for new antimicrobials to treat fluoroquinolone-resistant Campylobacter and Shigella [6]. If AMR bacteria become more common in NHPs, potential spillover events may occur to humans leading to both serious public health consequences and erosion of public trust in our research endeavors. The authors did not monitor any bacterial resistance patterns before or after the treatment or report antimicrobial susceptibility of common bacteria identified within the colony. [...]if this approach is used, it must be reported in the literature in the methods section of papers to promote research reproducibility.