Double functionalized haemocompatible silver nanoparticles control cell inflammatory homeostasis

Infection, trauma, and autoimmunity trigger tissue inflammation, often leading to pain and loss of function. Therefore, approaches to control inflammation based on nanotechnology principles are being developed in addition to available methods. The metal-based nanoparticles are particularly attractiv...

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Bibliographic Details
Published in:PloS one 2022-10, Vol.17 (10), p.e0276296-e0276296
Main Authors: Kumawat, Mamta, Madhyastha, Harishkumar, Singh, Mandeep, Revaprasadu, Neerish, Srinivas, Sangly P, Daima, Hemant Kumar
Format: Article
Language:English
Subjects:
Amino acids
Antibiotics
Antioxidants
Apoptosis
Autoimmunity
Bacterial infections
Bioavailability
Biocompatibility
Biology and Life Sciences
Biomedical materials
Care and treatment
Corona
Curcumin
Cytokines
Cytotoxicity
Design and construction
Drugs
Engineering and Technology
Gene expression
Health aspects
Homeostasis
IL-1β
Infections
Inflammation
Interleukin 6
Isoniazid
Kinases
Lipopolysaccharides
Macrophages
Medical research
Medicine and Health Sciences
Medicine, Experimental
Nanomedicine
Nanoparticles
Nanotechnology
Pain
Physical Sciences
Physicochemical properties
Phytochemicals
Potassium
Quercetin
Reagents
Scavenging
Silver
Toxicity
Trauma
Tumor necrosis factor-TNF
Tumor necrosis factor-α
Tyrosine
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Summary:Infection, trauma, and autoimmunity trigger tissue inflammation, often leading to pain and loss of function. Therefore, approaches to control inflammation based on nanotechnology principles are being developed in addition to available methods. The metal-based nanoparticles are particularly attractive due to the ease of synthesis, control over physicochemical properties, and facile surface modification with different types of molecules. Here, we report curcumin conjugated silver (Cur-Ag) nanoparticles synthesis, followed by their surface functionalization with isoniazid, tyrosine, and quercetin, leading to Cur-Ag.sup.INH, Cur-Ag.sup.Tyr, and Cur-Ag.sup.Qrc nanoparticles, respectively. These nanoparticles possess radical scavenging capacity, haemocompatibility, and minimal cytotoxicity to macrophages. Furthermore, the nanoparticles inhibited the secretion of pro-inflammatory cytokines such as interleukin-6, tumor necrosis factor-[alpha], and interleukin-1[beta] from macrophages stimulated by lipopolysaccharide (LPS). The findings reveal that the careful design of surface corona of nanoparticles could be critical to increasing their efficacy in biomedical applications.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0276296